{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:40:16Z","timestamp":1711111216613},"reference-count":112,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Hintergrund: Die Aufmerksamkeitsdefizit-Hyperaktivit\u00e4tsst\u00f6rung (ADHS) geht mit einer Vielzahl unterschiedlicher Komorbidit\u00e4ten einher, die sich zum Teil als Komplikation und in Folge der Kernsymptomatik, aber auch parallel zusammen mit der Grunderkrankung entwickeln k\u00f6nnen. Eine wichtige S\u00e4ule im Rahmen des multimodalen Konzepts zur Behandlung der ADHS stellt die medikament\u00f6se Behandlung, v. a. mit Psychostimulanzien, dar. Verschr\u00e4nkt mit psychotherapeutischen und psychosozialen Ma\u00dfnahmen bewirkt eine Stimulanzienmedikation in vielen F\u00e4llen einen zufriedenstellenden R\u00fcckgang der Hauptsymptome des St\u00f6rungsbildes und kann hierdurch auch zu einer Verminderung der Komorbidit\u00e4ten f\u00fchren. Gelingt dies nicht ausreichend, dann sollten medikament\u00f6se Behandlungsstrategien mit anderen Substanzen \u00fcberlegt werden, die zunehmend als Alternative oder in Kombination mit den Stimulanzien die komorbiden Symptome positiv beeinflussen. Fragestellung: Der vorliegende Beitrag gibt eine \u00dcbersicht der medikament\u00f6sen Behandlungsoptionen f\u00fcr verschiedene Komorbidit\u00e4ten, d. h. affektive St\u00f6rungen, aggressive Verhaltensst\u00f6rungen sowie Ticst\u00f6rungen. Besondere Beachtung kommt dabei der M\u00f6glichkeit kombinierter Behandlungsm\u00f6glichkeiten mit Psychostimulanzien zu. Dar\u00fcber hinaus werden in Form von Algorithmen Vorschl\u00e4ge zu medikament\u00f6sen Behandlungsstrategien unterbreitet, die sich an den im Vordergrund stehenden klinischen Leitsymptomen orientieren. Methodik: Auf der Basis einer Medline-Recherche erfolgt eine kritische \u00dcbersicht der evidenzbasierten Literatur und praktischer Erfahrungen. Ergebnisse: Im Ergebnis bewirkt der individuell titrierte Einsatz von Stimulanzien zur Behandlung der Kernsymptome der ADHS oft zugleich einen zufrieden stellenden R\u00fcckgang der komorbiden Symptome. Stehen diese aber zunehmend im Vordergrund des klinischen Beschwerdebildes, kann der Einsatz von Antidepressiva oder Neuroleptika zur prim\u00e4ren oder gleichberechtigten Behandlungsoptionen werden. 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