{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:53:36Z","timestamp":1694638416706},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:p> Wir berichten \u00fcber einen Patienten, der unter Lamotrigin (LTG) zur Behandlung einer depressiven Symptomatik mit Stimmungsschwankungen und aggressiven Durchbr\u00fcchen 10 Tage nach Therapiebeginn eine exanthemat\u00f6se Hautreaktion entwickelte, welche nach Absetzen von LTG reversibel war. Wir diskutieren unerw\u00fcnschte Arzneimittelwirkungen unter LTG, insbesondere Hautreaktionen und deren Risikofaktoren, die Massnahmen zur Reduktion der H\u00e4ufigkeit dieser Hautreaktionen sowie eine Studie, in der Patienten, welche unter LTG ein Exanthem entwickelt hatten, mit sehr tiefen Anfangsdosen kontrolliert reexponiert wurden. <\/jats:p>","DOI":"10.1024\/1661-8157\/a000113","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T03:31:46Z","timestamp":1268796706000},"page":"337-345","source":"Crossref","is-referenced-by-count":1,"title":["Lamotrigin und die Haut"],"prefix":"10.1024","volume":"99","author":[{"given":"R\u00e4tz","family":"Bravo","sequence":"first","affiliation":[{"name":"Abteilung f\u00fcr klinische Pharmakologie und Toxikologie und Regionales Pharmacovigilance-Zentrum Basel, Universit\u00e4tsspital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Psychiatrische Dienste, Spital STS AG, Thun"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Haschke","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr klinische Pharmakologie und Toxikologie, Universit\u00e4tsspital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a000113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:20:19Z","timestamp":1652005219000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a000113"}},"subtitle":["Lamotrigin-associated Skin Disease"],"short-title":[],"issued":{"date-parts":[[2010,3,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,3,1]]}},"alternative-id":["10.1024\/1661-8157\/a000113"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a000113","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,1]]}}}