{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T15:12:31Z","timestamp":1719933151955},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:p> F\u00fcr Kinder und Jugendliche mit rheumatologischen Erkrankungen, welche in der Schweiz mit TNF-\u03b1-Blockern behandelt werden, wurde ein Register angelegt, um den Langzeitverlauf der Krankheit, die Effektivit\u00e4t der Behandlung und unerw\u00fcnschte Wirkungen zu erfassen. 106 Patienten (68 weiblich\/38 m\u00e4nnlich) wurden eingeschlossen. 61 Patienten wurden mit Etanercept (Enbrel\u00ae) und 45 mit Infliximab (Remicade\u00ae) behandelt, 26% erhielten zus\u00e4tzlich Kortikosteroide und 75% Methotrexat. Die subjektive Krankheitsaktivit\u00e4t drei Monate nach Therapiebeginn mit TNF-\u03b1-Blockern war bei 81% besser, schlechter bei 4% und gleichbleibend bei 15% der Patienten. Es wurden insgesamt 24 Ereignisse von unerw\u00fcnschten Wirkungen bei 21 Patienten gemeldet. Die Therapie mit TNF-\u03b1-Blockern scheint f\u00fcr Kinder und Jugendliche mit rheumatologischen Erkrankungen sicher und wirksam zu sein. <\/jats:p>","DOI":"10.1024\/1661-8157\/a000144","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T02:32:06Z","timestamp":1274927526000},"page":"649-654","source":"Crossref","is-referenced-by-count":2,"title":["Schweizerisches Register f\u00fcr TNF-\u03b1-Blocker bei Kindern und Jugendlichen mit rheumatologischen Erkrankungen"],"prefix":"10.1024","volume":"99","author":[{"family":"Sauvain","sequence":"first","affiliation":[{"name":"Unikinderklinik f\u00fcr Kinderheilkunde+Uniklinik f\u00fcr Rheumatologie, Klinische Immunologie+Allergologie, Inselspital, Universit\u00e4tsspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Schalm","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Rheumatologie, Klinische Immunologie und Allergologie, Inselspital, Universit\u00e4tsspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"B\u00e9rthet","sequence":"additional","affiliation":[{"name":"Kinderklinik, Kantonsspital Aarau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bolz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tskinderspital beider Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Universit\u00e4tskinderklinik, Kinderspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hofer","sequence":"additional","affiliation":[{"name":"Service de p\u00e9diatrie, CHUV, Lausanne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Kaiser","sequence":"additional","affiliation":[{"name":"Kinderspital, Luzerner Kantonsspital Luzern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Saurenmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tskinderklinik, Kinderspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bolt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tskinderklinik f\u00fcr Kinderheilkunde, Inselspital, Universit\u00e4tsspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a000144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:04:16Z","timestamp":1652004256000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a000144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,5,1]]}},"alternative-id":["10.1024\/1661-8157\/a000144"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a000144","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,1]]}}}