{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:21:23Z","timestamp":1761895283957},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:p> Die interstitielle Zystitis, erstmals 1887 als entz\u00fcndliche Erkrankung der Harnblasenwand beschrieben, gilt heute als eine h\u00e4ufige Erkrankung mit hoher Dunkelziffer. Grund f\u00fcr die Unterdiagnose sind vielfach zu strikte Ausschlusskriterien. Die Erkrankung l\u00e4sst sich bereits durch sorgf\u00e4ltige Anamneseerhebung und klinische Untersuchung im Fr\u00fchstadium erkennen und mittels multimodaler Therapieans\u00e4tze erfolgversprechend behandeln. Neben der symptomorientierten oralen Therapie stellen lokale Instillationen von Bestandteilen der sch\u00fctzenden Glykosaminoglykan-Schicht, deren gest\u00f6rte Integrit\u00e4t als Schl\u00fcsselrolle in der Pathogenese der interstitiellen Zystitis gilt, den h\u00e4ufigsten Therapieansatz dar. <\/jats:p>","DOI":"10.1024\/1661-8157\/a000441","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T13:34:35Z","timestamp":1305552875000},"page":"221-227","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostik und Therapie der interstitiellen Zystitis"],"prefix":"10.1024","volume":"100","author":[{"family":"Meyer","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Urologie, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Gregorin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Schmid","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a000441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:19:35Z","timestamp":1652005175000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,2,1]]}},"alternative-id":["10.1024\/1661-8157\/a000441"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a000441","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}