{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:41:40Z","timestamp":1652006500831},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p> Wir berichten \u00fcber eine 75-j\u00e4hrige Patientin mit jahrelangem Pruritus sowie persistierender Erh\u00f6hung der Cholestaseparameter. Potentiell hepatotoxische Medikamente wurden gestoppt; eine Abdomensonographie war unauff\u00e4llig. Die gleichzeitige Erh\u00f6hung der antimitochondrialen Antik\u00f6rper ist in diesem Kontext praktisch beweisend f\u00fcr das Vorliegen einer prim\u00e4r bili\u00e4ren Zirrhose. Im Sinne einer krankheitsmodulierenden Therapie wird Ursodeoxychols\u00e4ure (13-15 mg\/kg\/d, verteilt auf zwei orale Dosen) eingesetzt. Im Zusammenhang mit der prim\u00e4r bili\u00e4ren Zirrhose kommt es geh\u00e4uft zu Hypothyreose, Osteoporose und Hypercholesterin\u00e4mien. <\/jats:p>","DOI":"10.1024\/1661-8157\/a000595","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:07:51Z","timestamp":1359770871000},"page":"865-867","source":"Crossref","is-referenced-by-count":0,"title":["(Fast) beschwerdefreie Patientin, aber konstant erh\u00f6hte Cholestaseparameter"],"prefix":"10.1024","volume":"100","author":[{"family":"Kherb\u00e8che","sequence":"first","affiliation":[{"name":"Praxisassistenzarzt in allgemeinmedizinischer Hausarztpraxis, Thal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a000595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:21:46Z","timestamp":1652005306000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a000595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":0,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2011,7,1]]}},"alternative-id":["10.1024\/1661-8157\/a000595"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a000595","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}