{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:41:30Z","timestamp":1652006490212},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p> Eine 77-j\u00e4hrige Patientin entwickelte wenige Tage nach Erh\u00f6hung der Betablockerdosis und zus\u00e4tzlicher Gabe von Verapamil bei tachykardem Vorhofflimmern einen kardiogenen Schock. Nach Ausschluss anderer Differenzialdiagnosen erfolgte die empfohlene Therapie mit Katecholaminen, Kalziumsalzen, hochdosiertem Insulin sowie Phosphodiesterasehemmer, worunter der Schockzustand jedoch refrakt\u00e4r war. Wenige Stunden nach Applikation des Kalzium-Sensitizers Levosimendan zeigte sich eine deutliche Verbesserung der Herzleistung. Eingegangen wird auf die Gefahren der kombinierten Gabe negativ-inotroper Medikamente zur Frequenzkontrolle bei Vorhofflimmern sowie auf den Wirkmechanismus auf zellul\u00e4rer Ebene aller empfohlenen Therapeutika bei \u00fcberm\u00e4ssiger Wirkung von Betablockern und Kalziumantagonisten. <\/jats:p>","DOI":"10.1024\/1661-8157\/a000989","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:08:12Z","timestamp":1359770892000},"page":"919-922","source":"Crossref","is-referenced-by-count":1,"title":["Das abgew\u00fcrgte Herz"],"prefix":"10.1024","volume":"101","author":[{"family":"Furrer","sequence":"first","affiliation":[{"name":"Interdisziplin\u00e4re Intensivstation, Stadtspital Waid Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Giambarba","sequence":"additional","affiliation":[{"name":"Interdisziplin\u00e4re Intensivstation, Stadtspital Waid Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a000989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:14:38Z","timestamp":1652004878000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a000989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":0,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,7,1]]}},"alternative-id":["10.1024\/1661-8157\/a000989"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a000989","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}