{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:23:28Z","timestamp":1648700608179},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> Zusammenfassung. Der nat\u00fcrliche Verlauf einer Hepatitis-B-Virus(HBV)-Infektion ist komplex und wird einerseits durch das Alter zum Zeitpunkt der Infektion, anderseits durch Komorbidit\u00e4ten bzw. Koinfektionen und zum Teil noch nicht identifizierte Faktoren bestimmt. Das HBV wird nie komplett eliminiert. Das Erreichen des inaktiven Tr\u00e4gerstatus ist aber ein realistisches Therapieziel. Zur Therapie stehen Nukleosid\/Nukleotid-Analoga sowie pegyliertes Interferon-alpha zur Verf\u00fcgung. Screening von bestimmten Patientengruppen und eine generelle Impfung sind wichtige prophylaktische Massnahmen. Die chronische Hepatitis-C-Virus(HCV)-Infektion f\u00fchrt in circa einem Drittel der F\u00e4lle zur Leberzirrhose. Eine Therapie ist generell ab Fibrosestadium Metavir 2 indiziert. Neue DAA (directly acting antivirals) erlauben kurzfristige, hochpotente und nebenwirkungsarme Therapieschemata. <\/jats:p>","DOI":"10.1024\/1661-8157\/a002207","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T19:23:18Z","timestamp":1449688998000},"page":"1393-1397","source":"Crossref","is-referenced-by-count":0,"title":["Update chronische Hepatitis B und C"],"prefix":"10.1024","volume":"104","author":[{"given":"Benedetta","family":"Terziroli Beretta-Piccoli","sequence":"first","affiliation":[{"name":"Epatocentro Ticino, Lugano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Schranz","sequence":"additional","affiliation":[{"name":"Epatocentro Ticino, Lugano"},{"name":"Hepatologie, Inselspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Gottardi","sequence":"additional","affiliation":[{"name":"Epatocentro Ticino, Lugano"},{"name":"Hepatologie, Inselspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Cerny","sequence":"additional","affiliation":[{"name":"Epatocentro Ticino, Lugano"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a002207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T09:37:00Z","timestamp":1615973820000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a002207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":0,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1024\/1661-8157\/a002207"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a002207","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}