{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T10:14:44Z","timestamp":1649153684238},"reference-count":13,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p> Zusammenfassung. Zur Beurteilung einer relevanten Pubert\u00e4tsst\u00f6rung ist es essenziell, die Physiologie der Pubert\u00e4t zu kennen. Bei M\u00e4dchen ist die pr\u00e4mature Thelarche ein h\u00e4ufiger Konsultationsgrund. Meist ben\u00f6tigt diese keine weitere Therapie, muss aber gegen eine Pubertas praecox abgegrenzt werden. Diese braucht in jedem Fall weitere Diagnostik und m\u00f6glicherweise auch eine pubert\u00e4tshemmende Therapie. Bei Knaben ist hingegen die Pubert\u00e4tsgyn\u00e4komastie und die Pubertas tarda ein h\u00e4ufigerer Vorstellungsgrund. Beides geht oft mit einem erheblichen Leidensdruck einher. Die physiologische Pubert\u00e4tsgyn\u00e4komastie ist in den meisten F\u00e4llen nach 6\u201318 Monaten spontan r\u00fcckl\u00e4ufig und bedarf nur selten einer weiteren Abkl\u00e4rung oder Therapie. Die Pubertas tarda tritt h\u00e4ufig im Rahmen einer konstitutionellen Entwicklungsverz\u00f6gerung auf, differenzialdiagnostisch muss aber ein permanenter Hypogonadismus ausgeschlossen werden. <\/jats:p>","DOI":"10.1024\/1661-8157\/a002594","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T16:42:42Z","timestamp":1486485762000},"page":"127-133","source":"Crossref","is-referenced-by-count":1,"title":["Zu fr\u00fch? Zu sp\u00e4t? Ein \u00dcberblick \u00fcber die                Pubert\u00e4t und h\u00e4ufige Pubert\u00e4tsst\u00f6rungen"],"prefix":"10.1024","volume":"106","author":[{"given":"Melanie","family":"Hess","sequence":"first","affiliation":[{"name":"P\u00e4diatrische                Endokrinologie\/Diabetologie, Universit\u00e4tskinderspital beider Basel UKBB,                Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Zumsteg","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische                Endokrinologie\/Diabetologie, Universit\u00e4tskinderspital beider Basel UKBB,                Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-015-3330-y"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-007-0229-3"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2116"},{"key":"c4","first-page":"229","volume":"38","author":"Largo RH","year":"1983","journal-title":"Helv Paediatr Acta"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-011-2609-x"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2919"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1789"},{"key":"c8","author":"D\u00f6rr HG","journal-title":"AWMF-Register Nr 027\/028"},{"key":"c9","author":"Sansone A","year":"2016","journal-title":"Endocrine"},{"key":"c10","first-page":"279","volume":"10","author":"Dohle GR AS","year":"2013","journal-title":"J Reproduktionsmed Endokrinol"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.01.002"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.112"},{"key":"c13","author":"Braunstein GD","year":"2011","journal-title":"Greenspan\u2019s: Basic & Clinical Endocrinology; 9th edition, McGrawHill Medical"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a002594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T03:06:44Z","timestamp":1615950404000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a002594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1024\/1661-8157\/a002594"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a002594","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}