{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:07:17Z","timestamp":1649146037078},"reference-count":31,"publisher":"Hogrefe Publishing Group","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2017,10]]},"abstract":" Zusammenfassung. Die Kombination von fluktuierender und belastungsabh\u00e4ngiger Diplopie, Ptose und paretischem Lidschluss \u2013 unter Aussparung der Pupillomotorik \u2013 ist pathognomonisch f\u00fcr die okul\u00e4re Myasthenie. In den ersten zwei Jahren kommt es bei 80 % der Patienten zu einer Generalisierung, mit Entwicklung bulb\u00e4rer Beschwerden und Schw\u00e4che in der Extremit\u00e4tenmuskulatur. Die Diagnose der okul\u00e4ren Myasthenie gelingt wegen des oft schleichenden Auftretens, der schwierigen Abgrenzung zu anderen neuroophthalmologischen und neurologischen Krankheitsbildern und der niedrigen Sensitivit\u00e4t der apparativen Untersuchungen oft nur mit Versp\u00e4tung. Eine rasche Diagnose ist wichtig, da effiziente Therapieoptionen eine gute Symptomkontrolle erlauben und weil eine fr\u00fche Immunsuppression die H\u00e4ufigkeit der Konversion zu einer generalisierten Form reduzieren kann. <\/jats:p>","DOI":"10.1024\/1661-8157\/a002796","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T13:25:02Z","timestamp":1507123502000},"page":"1107-1114","source":"Crossref","is-referenced-by-count":0,"title":["Okul\u00e4re Myasthenie"],"prefix":"10.1024","volume":"106","author":[{"given":"Yulia","family":"Valko","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad P.","family":"Weber","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Universit\u00e4tsspital Z\u00fcrich"},{"name":"Klinik f\u00fcr Ophthalmologie, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00145-3"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21191"},{"key":"c3","first-page":"35","volume":"8","author":"Wing Lok AU MRCP (UK)","year":"2003","journal-title":"Neurol J Southeast Asia"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12599"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.11.1663"},{"key":"c6","doi-asserted-by":"crossref","unstructured":"Norwood F , \n Dhanjal M , \n Hill M , et al. : Myasthenia in pregnancy: best practice guidelines from a U.K. multispecialty working group. J Neurol Neurosurg Psychiatry \n 2014; 85 : 538\u2013543.","DOI":"10.1136\/jnnp-2013-305572"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1105"},{"key":"c8","doi-asserted-by":"crossref","unstructured":"Beghi E , \n Antozzi C , \n Batocchi AP , et al.: Prognosis of myasthenia gravis: a multicenter follow-up study of 844 patients. J Neurol Sci 1991; 106 : 213\u2013220.","DOI":"10.1016\/0022-510X(91)90260-E"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1159\/000065639"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003985"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.063404"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050059"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.2.156"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200312000-00002"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.2.243"},{"key":"c16","doi-asserted-by":"crossref","unstructured":"Gorelick PB , \n Rosenberg M , \n Pagano RJ : Enhanced ptosis in myasthenia gravis. Arch Neurol \n 1981; 38 : 531.","DOI":"10.1001\/archneur.1981.00510080093017"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1965.00970040219016"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002920"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00709-5"},{"key":"c20","unstructured":"Odel JG , \n Winterkorn JM , Behrens MM: The sleep test for myasthenia gravis. A safe alternative to Tensilon. J Clin Neuroophthalmol \n 1991; 11 : 288\u2013292."},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002383"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140504"},{"key":"c23","doi-asserted-by":"crossref","unstructured":"Nagia L, \n Lemos J , \n Abusamra K , \n Cornblath WT , Eggenberger ER: Prognosis of ocular myasthenia gravis: Retrospective multicenter analysis. Ophthalmology \n 2015; 122 : 1517\u20131521.","DOI":"10.1016\/j.ophtha.2015.03.010"},{"key":"c24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51317.x"},{"key":"c25","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.5.752"},{"key":"c26","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12359"},{"key":"c27","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"c28","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24769"},{"key":"c29","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.12.1792"},{"key":"c30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602489"},{"key":"c31","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.4.332"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a002796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T21:12:57Z","timestamp":1615929177000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a002796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":31,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1024\/1661-8157\/a002796"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a002796","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}