{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T18:26:07Z","timestamp":1712687167196},"reference-count":10,"publisher":"Hogrefe Publishing Group","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p> Zusammenfassung. Das Multiple Myelom macht 1 % aller Malignome aus, wobei die Inzidenz mit zunehmendem Alter steigt. Das Krankheitsbild verl\u00e4uft sehr heterogen und die Symptome sind vielgestaltig. W\u00e4hrend sich einige Patienten mit unspezifischen Beschwerden,wie M\u00fcdigkeit, Lethargie und Infektneigung pr\u00e4sentieren, gibt es Notfallsituationen wie die Hyperkalzi\u00e4mie, die R\u00fcckenmarkskompression oder das Hyperviskosit\u00e4tssyndrom, die einer sofortigen Therapieeinleitung bed\u00fcrfen. Ziel dieses Artikels ist es, einen \u00dcberblick \u00fcber Symptome und Notfallsituationen, die wichtigsten Abkl\u00e4rungsstrategien und die Therapie zu geben. <\/jats:p>","DOI":"10.1024\/1661-8157\/a002984","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T06:00:31Z","timestamp":1530684031000},"page":"749-754","source":"Crossref","is-referenced-by-count":1,"title":["CME: Das Multiple Myelom \u2013 ein \u00dcberblick"],"prefix":"10.1024","volume":"107","author":[{"given":"Michelle","family":"Br\u00e4utigam","sequence":"first","affiliation":[{"name":"Universit\u00e4tsspital, Klinik f\u00fcr Innere Medizin, Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Biskup","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital, Klinik f\u00fcr Innere Medizin, Basel"},{"name":"Shanghai University of Medicine and Health Sciences, Shanghai, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24402"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24802"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx096"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.14694\/EDBK_159009"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.162693"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-568915"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117176"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a002984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T04:51:54Z","timestamp":1615956714000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a002984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":10,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1024\/1661-8157\/a002984"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a002984","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}