{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:42:50Z","timestamp":1779889370210,"version":"3.53.1"},"reference-count":80,"publisher":"Hogrefe Publishing Group","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p> Zusammenfassung. Hypophysenadenome (HA) sind gutartige Tumoren aus parenchymat\u00f6sen Zellen des Hypopysenvorderlappens. Es wird zwischen endokrin-inaktiven HA und hormonsezernierenden HA differenziert. Die Symptomkonstellation ist abh\u00e4ngig von der hormonellen \u00dcber- oder Unterfunktion und dem durch das HA erzeugten Masseneffekt. Neben Kopfschmerzen pr\u00e4sentieren sich HA h\u00e4ufig mit Visusst\u00f6rungen sowie Gesichtsfeldausf\u00e4llen als Folge der Kompression des Chiasma opticum. Die chirurgische Resektion \u00fcber einen transsphenoidalen Zugang ist die bevorzugte Therapieoption f\u00fcr symptomatische oder gr\u00f6ssenprogrediente HA. Moderne Techniken wie intraoperative hochaufl\u00f6sende MR-Bildgebung unterst\u00fctzen den Chirurgen in der maximal sicheren Resektion. Eine Sonderrolle spielen symptomatische Prolaktinome, die in erster Linie medikament\u00f6s mit Dopaminagonisten therapiert werden sollten. Aufgrund der Komplexit\u00e4t der Erkrankung ist eine interdisziplin\u00e4re Betreuung der Patienten durch Neurochirurgen und Endokrinologen in einem Zentrum mit hohen Fallzahlen empfohlen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003035","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:07:49Z","timestamp":1532520469000},"page":"825-835","source":"Crossref","is-referenced-by-count":12,"title":["Modernes Management von Hypophysenadenomen \u2013 gegenw\u00e4rtiger Stand in                Diagnostik, Therapie und Nachsorge"],"prefix":"10.1024","volume":"107","author":[{"given":"Nicolai","family":"Maldaner","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie, Klinisches Neurozentrum, Universit\u00e4tsspital                Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Serra","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie, Klinisches Neurozentrum, 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