{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:14:45Z","timestamp":1775499285235,"version":"3.50.1"},"reference-count":25,"publisher":"Hogrefe Publishing Group","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,10]]},"abstract":" Zusammenfassung. Ethylenglykol ist ein s\u00fcsslich schmeckender Alkohol (einfachster zweiwertiger Alkohol, Synonym \u00abGlykol\u00bb), der in handels\u00fcblichen Frostschutzmitteln und anderen industriellen L\u00f6sungen verwendet wird. Ohne ad\u00e4quate Therapiemassnahmen kann eine Intoxikation mit Ethylenglykol zu einer schweren metabolischen Azidose, zum akuten Nierenversagen und zum Tod f\u00fchren. Nach gastrointestinaler Resorption findet die Metabolisierung \u00fcberwiegend hepatisch, unter anderem durch die Alkoholdehydrogenase, statt und resultiert in einer schweren metabolischen Azidose mit Anionenl\u00fccke und der Bildung von Kalziumoxalat-Kristallen, die sich in verschiedenen Geweben ablagern k\u00f6nnen. In der Niere f\u00fchrt dies zur akuten Tubulusnekrose mit potenziell reversiblem Nierenversagen. Therapeutisch entscheidend ist die schnellstm\u00f6gliche Inhibition der Alkoholdehydrogenase durch Fomepizol oder Ethanol, um die Bildung toxischer Metaboliten zu verhindern. Die H\u00e4modialyse bietet die effektivste Methode der sekund\u00e4ren Dekontamination. 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