{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:29:31Z","timestamp":1649201371756},"reference-count":9,"publisher":"Hogrefe Publishing Group","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p> Zusammenfassung. Die herausfordernde Therapie eines schweren, unkontrollierbaren Asthma bronchiale hat prim\u00e4r eine ausreichende Symptomkontrolle und die Minimierung der Exazerbationsrate zum Ziel. Ist die Symptomkontrolle trotz ausgebauter medikament\u00f6ser Therapie nur sehr schwer zu erreichen, kann anstatt der nebenwirkungsreichen Kortikosteroidtherapie die Indikation f\u00fcr Biologika gestellt werden. Ziel dieses Artikels ist es, diese verschiedenen Asthma-Therapiepfade aufzuzeigen, Diagnosekriterien, aber auch praktische Erfahrungen durch deren Anwendung bei Patienten zu beschreiben. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003076","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T04:00:29Z","timestamp":1539748829000},"page":"1129-1135","source":"Crossref","is-referenced-by-count":0,"title":["CME: Mepolizumab, ein weiterer Baustein der individualisierten Therapie                des schweren Asthma bronchiale"],"prefix":"10.1024","volume":"107","author":[{"given":"Sigrid","family":"Platzer","sequence":"first","affiliation":[{"name":"Departement Innere Medizin, Fachbereich                Pneumologie\/Schlafmedizin, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fehr","sequence":"additional","affiliation":[{"name":"Departement Innere Medizin, Kantonsspital                Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsogyal","family":"Latshang","sequence":"additional","affiliation":[{"name":"Departement Innere Medizin, Fachbereich                Pneumologie\/Schlafmedizin, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","unstructured":"Global Initiative for Asthma Global                   strategy for asthma management and prevention, 2017.                   http:\/\/www.ginasthma.org. 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