{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:27:24Z","timestamp":1756571244798},"reference-count":27,"publisher":"Hogrefe Publishing Group","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,11]]},"abstract":" Zusammenfassung. Die Pr\u00e4eklampsie ist eine Multisystemerkrankung, die vorwiegend zu einer systemischen Beeintr\u00e4chtigung der m\u00fctterlichen Endothelfunktion f\u00fchrt. Eine Dysbalance von proangiogenen und antiangiogenen Faktoren ist dabei massgeblich beteiligt. Die vaskul\u00e4re Erkrankung f\u00fchrt zur klinischen Manifestation der Symptome wie arterieller Hypertonie und zur Beteiligung der Endorgane, v.a. Niere, Leber und Gehirn. Das klassische Diagnosekriterium \u00abProteinurie\u00bb ist gem\u00e4ss internationaler Empfehlungen nicht mehr obligat zur Diagnosestellung erforderlich, sondern nur noch ein m\u00f6gliches Kriterium und kann durch die Kriterien m\u00fctterliche Organbeteiligung oder fetale Wachstumsretardierung ersetzt werden. Die Weisskittelhypertonie wird in die Klassifikation der hypertensiven Erkrankungen zus\u00e4tzlich aufgenommen. Die Begrifflichkeit \u00ableichte\u00bb Pr\u00e4eklampsie wird im klinischen Setting wegen der potenziell raschen Verschlechterung und damit einhergehenden m\u00fctterlichen und fetalen Gef\u00e4hrdung nicht empfohlen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003100","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T08:30:21Z","timestamp":1543393821000},"page":"1333-1337","source":"Crossref","is-referenced-by-count":1,"title":["Pr\u00e4eklampsie: neue Definitionen"],"prefix":"10.1024","volume":"107","author":[{"given":"Leonhard","family":"Sch\u00e4ffer","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Geburtshilfe & Pr\u00e4nataldiagnostik, Kantonsspital Baden AG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"crossref","unstructured":"Say L, Chou D, Gemmill A, et al.: Global causes of maternal death: a WHO systematic analysis. 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