{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T08:49:14Z","timestamp":1648975754475},"reference-count":6,"publisher":"Hogrefe Publishing Group","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p> Zusammenfassung. Maligne Tumoren k\u00f6nnen durch eine paraneoplastische Hormonsekretion endokrine Krankheitsbilder verursachen, die sehr \u00e4hnlich sind den eigentlichen endokrinen Tumorerkrankungen. Die Kenntnis der paraneoplastischen endokrinen Syndrome erlaubt eine fr\u00fche Diagnose der malignen Grunderkrankung, und die gezielte endokrine Therapie reduziert Morbidit\u00e4t und Mortalit\u00e4t der betroffenen Patienten. Die h\u00e4ufigsten endokrinen Paraneoplasien sind die Hyperkalz\u00e4mie, humoral bedingt durch die Sekretion von PTHrP durch Tumorzellen (vor allem solide Tumoren wie Bronchus- und Mammakarzinom), und die Hyponatri\u00e4mie, verursacht durch eine inad\u00e4quate ADH-Sekretion (typischerweise durch das kleinzellige Bronchuskarzinom). Beide Tumorsyndrome k\u00f6nnen sich klinisch manifestieren und m\u00fcssen differenzialdiagnostisch beim laborchemischen Befund einer Hyperkalz\u00e4mie bzw. einer Hyponatri\u00e4mie in Betracht gezogen und je nach Ausmass therapiert werden. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003132","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T08:30:21Z","timestamp":1543393821000},"page":"1309-1315","source":"Crossref","is-referenced-by-count":0,"title":["CME: Paraneoplastische endokrine Syndrome"],"prefix":"10.1024","volume":"107","author":[{"given":"Christoph","family":"Henzen","sequence":"first","affiliation":[{"name":"Innere Medizin\/Endokrinologie und                Diabetologie, Luzerner Kantonsspital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"crossref","unstructured":"Pelosof LC,                      Gerber DE:                   Paraneoplastic syndromes: an approach to diagnosis and                   treatment. Mayo Clin                   Proc 2010; 85:                   838\u2013854.","DOI":"10.4065\/mcp.2010.0099"},{"key":"c2","doi-asserted-by":"crossref","unstructured":"Dimitriadis GK,                      Angelousi A,                      Weickert MO,                      Randeva HS,                   Kaltsas G, Grossman A: Paraneoplastic endocrine                   syndromes. Endocrine-Related                   Cancer 2017; 24:                   173\u2013190.","DOI":"10.1530\/ERC-17-0036"},{"key":"c3","doi-asserted-by":"crossref","unstructured":"Reisch N,                      Reincke M:                   Endokrine paraneoplastische Syndrome.                   Der Internist 2018;                59: 125\u2013133.","DOI":"10.1007\/s00108-017-0377-y"},{"key":"c4","doi-asserted-by":"crossref","unstructured":"Ellison DH,                      Berl T:                   The syndrome of inappropriate antidiuresis.                   N Engl J Med 2007;                356:                2064\u20132072.","DOI":"10.1056\/NEJMcp066837"},{"key":"c5","doi-asserted-by":"crossref","unstructured":"Minisola S,                      Pepe J,                      Piemonte S,                      Cipriani C:                   The diagnosis and management of hypercalcaemia.                   BMJ 2015; 350:                   h2723.","DOI":"10.1136\/bmj.h2723"},{"key":"c6","doi-asserted-by":"crossref","unstructured":"Jin J,                      Chung JO,                      Chung MY,                      Cho DH,                      Chung DJ:                   Clinical characteristics, causes and survival in 115 cancer                   patients with parathyroid hormone related protein-mediated                   hypercalcemia. J Bone                   Metab 2017; 24:                   249\u2013255.","DOI":"10.11005\/jbm.2017.24.4.249"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T09:04:47Z","timestamp":1615971887000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":6,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1024\/1661-8157\/a003132"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003132","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}