{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T22:06:02Z","timestamp":1648937162046},"reference-count":26,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2019,1]]},"abstract":" Zusammenfassung. Die spontane Fr\u00fchgeburt ist ein Syndrom, das durch multiple Mechanismen ausgel\u00f6st wird. Angesichts der pathophysiologischen Heterogenit\u00e4t der Fr\u00fchgeburt kann ein einzelner Biomarker nicht die geforderten hohen negativen und positiven Pr\u00e4diktivwerte aufzeigen. Aus klinischer Sicht hat sich die Anamnese, sonografische Messung der Zervix-L\u00e4nge und Test auf plazentares Alpha-Microglobulin-1 (PAMG-1) aus dem zervikovaginalen Sekret durchgesetzt. Weitere prospektive, gross angelegte longitudinale Studien m\u00fcssen die kombinierte Verwendung neuer Biomarker validieren. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003137","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:28:28Z","timestamp":1547022508000},"page":"53-57","source":"Crossref","is-referenced-by-count":0,"title":["Fr\u00fchgeburtsscreening: Was ist wirklich sinnvoll?"],"prefix":"10.1024","volume":"108","author":[{"given":"Sofia","family":"Amylidi-Mohr","sequence":"first","affiliation":[{"name":"Geburtshilfe und Feto-Maternale Medizin, Universit\u00e4tsklinik f\u00fcr Frauenheilkunde, Inselspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Mueller","sequence":"additional","affiliation":[{"name":"Geburtshilfe und Feto-Maternale Medizin, Universit\u00e4tsklinik f\u00fcr Frauenheilkunde, Inselspital Bern"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","unstructured":"Christianson A, Howson CP, Modell B: March of Dimes. 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