{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T21:29:40Z","timestamp":1649107780352},"reference-count":22,"publisher":"Hogrefe Publishing Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2019,7]]},"abstract":" Zusammenfassung. Raumforderungen in der Hypophyse haben unterschiedliche Entit\u00e4ten. Am h\u00e4ufigsten kommen benigne Hypophysenvorderlappenadenome vor. Viele davon werden inzidentell entdeckt und sind asymptomatisch. Andere machen sich durch eine Beeintr\u00e4chtigung der Hypophysenfunktion (Hypopituitarismus), eine gesteigerte Hormonsekretion (Prolaktinom, Akromegalie, Hypercortisolismus) oder durch neurologische Symptome (bitemporale Hemianopsie) bemerkbar. Die Abkl\u00e4rung beinhaltet eine endokrinologische Labordiagnostik sowie ein MRT der Hypophyse. Bei N\u00e4he oder Kontakt zum Chiasma opticum ist zus\u00e4tzlich eine Gesichtsfeldpr\u00fcfung erforderlich. Bei symptomatischen Raumforderungen ist die Therapie der Wahl meist eine Operation \u00fcber den transsphenoidalen Zugang. Eine Ausnahme bilden Prolaktinome, die in erster Linie medikament\u00f6s behandelt werden. Perioperativ ist eine engmaschige Kontrolle hinsichtlich eines Hypopituitarismus wichtig. Ein interdisziplin\u00e4rer Austausch und das gemeinsame Festlegen des Prozederes erm\u00f6glichen die optimalste Betreuung der Patienten. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003263","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T05:00:21Z","timestamp":1562734821000},"page":"599-608","source":"Crossref","is-referenced-by-count":0,"title":["Interdisziplin\u00e4res Management von Hypophysentumoren"],"prefix":"10.1024","volume":"108","author":[{"given":"Barbara","family":"Bischofberger-Baumann","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie, Osteologie und Stoffwechselkrankheiten, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ebert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie, Osteologie und Stoffwechselkrankheiten, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Hader","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Radiologie und Nuklearmedizin, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Fournier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie, Spital Sitten"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bilz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie, Osteologie und Stoffwechselkrankheiten, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"crossref","unstructured":"Ostrom QT, Gittleman H, Fulop J, et al.: CBTRUS Statistical Report: Primary brain and central nervous system tumors dDiagnosed in the United States in 2008\u20132012 Neuro Oncol 2015; 17 (S4): iv1.","DOI":"10.1093\/neuonc\/nov189"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090885"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-10-199405150-00001"},{"key":"c4","first-page":"675","volume":"15","author":"Chong BW","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"c5","first-page":"236","volume-title":"Medicine","volume":"78","author":"D Gsponer J","year":"1999"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02326"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0796"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1118"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1038\/340692a0"},{"key":"c10","first-page":"330","author":"Vallar L","year":"1987","journal-title":"Nature"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2017-104957"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327890"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.143.2.377"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0144"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03667.x"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1048"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19699"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.03.058"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1048"},{"key":"c20","first-page":"610","volume":"33","author":"Knosp E","year":"1993","journal-title":"Neurosurgery"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1692"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0788-8"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T02:34:58Z","timestamp":1615948498000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1024\/1661-8157\/a003263"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003263","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}