{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T04:16:00Z","timestamp":1681532160919},"reference-count":10,"publisher":"Hogrefe Publishing Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p> Zusammenfassung. Dank neuer Biologika stehen Patienten mit einem \u00abschwierig behandelbaren\u00bb Asthma bronchiale neue Therapieoptionen zur Verf\u00fcgung. Vor dem Einsatz solcher Medikamente ist jedes \u00abschwierig behandelbare\u00bb Asthma auf Faktoren zu \u00fcberpr\u00fcfen, die eine suffiziente Asthmakontrolle erschweren (z.B. ungen\u00fcgende Inhalationstechnik, Compliance, anhaltende Allergenexposition) und Asthma-aggravierende Co-Morbidit\u00e4ten (z.B. chronische Rhinitis, Reflux, Schlafapnoe) sollten gesucht und behandelt werden. F\u00fcr das Verst\u00e4ndnis des Wirkmechanismus der Biologika ist eine Ph\u00e4notypisierung unerl\u00e4sslich. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003293","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T06:00:21Z","timestamp":1567576821000},"page":"715-721","source":"Crossref","is-referenced-by-count":1,"title":["Ein schwierig behandelbares Asthma bronchiale muss nicht ein schweres                     Asthma bronchiale sein"],"prefix":"10.1024","volume":"108","author":[{"given":"Yvonne","family":"Nussbaumer-Ochsner","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin\/Pneumologie, Spit\u00e4ler Schaffhausen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","unstructured":"Global Initiative for Asthma                         (GINA): Global Strategy for Asthma Management and                         Prevention, 2019. www.ginasthma.org;                         letzter Zugriff: 09.07.2019."},{"key":"c2","unstructured":"GSK: Asthma                         control test. www.asthmacontroltest.com\/europe\/Switzerland; letzter                         Zugriff: 07.07.2019."},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.042"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.4414\/smf.2017.02903"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608969"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.052241"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01782-2017"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01824-2014"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31281-3"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T12:17:22Z","timestamp":1681474642000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1024\/1661-8157\/a003293"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003293","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}