{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:17:08Z","timestamp":1771553828415,"version":"3.50.1"},"reference-count":16,"publisher":"Hogrefe Publishing Group","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Zusammenfassung. Typhus ist zwar ein relativ seltenes Krankheitsbild in unseren Breitengraden, z\u00e4hlt aber zu den h\u00e4ufigsten Gr\u00fcnden f\u00fcr Fieber beim Reiser\u00fcckkehrer aus tropischen Gebieten, insbesondere bei Patienten aus S\u00fcd(ost)asien und Subsahara-Afrika. Zu den typischen klinischen Manifestationen beim Typhus geh\u00f6ren i) Puls-Temperatur-Dissoziation, ii) Eosinopenie, iii) Entfieberung \u00fcber mehrere Tage und iv) verschiedene Systemmanifestationen (z.B. Hepatitis). Der Goldstandard f\u00fcr die Diagnostik sind positive Blutkulturen. Die empirische antibiotische Therapie h\u00e4ngt stark vom Reiseland ab, da die Resistenzlage in den Endemiegebieten unterschiedlich ist. Die beste Pr\u00e4vention besteht in der Verwendung von hygienisch einwandfreiem Wasser und Vermeidung von rohen Speisen. Eine Typhusimpfung liefert ebenfalls einen gewissen Schutz. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003319","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T06:00:35Z","timestamp":1572415235000},"page":"937-943","source":"Crossref","is-referenced-by-count":1,"title":["CME: Typhus abdominalis \u2013 Klinik, Diagnostik, Therapie und                     Pr\u00e4vention"],"prefix":"10.1024","volume":"108","author":[{"given":"No\u00eblle","family":"Moser-van der Geest","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Departement f\u00fcr Innere Medizin,                     Stadtspital Triemli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Schibli","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Infektiologie, Departement f\u00fcr Innere                     Medizin, Stadtspital Triemli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars C.","family":"Huber","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Departement f\u00fcr Innere Medizin,                     Stadtspital Triemli"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1094"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3391-3"},{"key":"c3","first-page":"1000","volume":"05","author":"Oehri I","year":"2005","journal-title":"Schweiz Med Forum"},{"key":"c4","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/B978-1-4557-4801-3.00102-8","author":"Harris JB","year":"2015","journal-title":"Mandell, Douglass and Bennett\u2019s Principles and Practice of Infectious Diseases"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2018-0003"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006779"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30350-5"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6801a3"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit723"},{"key":"c10","first-page":"9589208","author":"Mogasale VV","year":"2018","journal-title":"J Environ Public Health 2018"},{"key":"c11","author":"Astral","journal-title":"Reisemedizinische Beratung"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1145"},{"key":"c13","doi-asserted-by":"crossref","unstructured":"Sahastrabuddhe S,                                 Saluja T:                         Overview of the typhoid conjugate vaccine pipeline: Current                         status and future plans. 2019;                             68(S1):                     S22\u2013S26.","DOI":"10.1093\/cid\/ciy884"},{"key":"c14","first-page":"CD001261","volume":"5","author":"Milligan R","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"c15","author":"WHO","journal-title":"Prequalification of Medicines"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32149-9"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T03:11:26Z","timestamp":1615950686000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":16,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1024\/1661-8157\/a003319"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003319","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}