{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:28:29Z","timestamp":1790710109710,"version":"4.1.0"},"reference-count":41,"publisher":"Hogrefe Publishing Group","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Zusammenfassung. Anorexia nervosa ist eine gef\u00e4hrliche Krankheit mit noch unbekannter \u00c4tiologie, die eine Vielzahl von endokrinen Auswirkungen verursacht. Charakteristisch f\u00fcr Anorexia nervosa sind eine reduzierte Nahrungsaufnahme und dadurch deutliches Untergewicht, sowie die Angst vor Gewichtszunahme. Oft haben Betroffene auch eine verzerrte Selbstwahrnehmung, Bewegungsdrang und eine ausbleibende Regelblutung. Anorexia nervosa ist schwierig zu behandeln, hat einen oft chronischen Verlauf und ist mit einem erh\u00f6hten Mortalit\u00e4tsrisiko verbunden. Die endokrinologischen Ver\u00e4nderungen treten in mehreren endokrinen Achsen auf, ihr Ausmass h\u00e4ngt mit dem Grad der Unterern\u00e4hrung zusammen. Ein niedriger Leptin-Serumspiegel, bedingt durch das Untergewicht, signalisiert dem Gehirn einen potenziell gef\u00e4hrlichen Energiemangel. Es kommt zu einer Kaskade von neuroendokrinen Anpassungsreaktionen, um dem Organismus das \u00dcberleben zu sichern. Die Auswirkungen des Hungerzustandes sind weitreichend und beeintr\u00e4chtigen Hypophyse, Schilddr\u00fcse, Nebennieren, Gonaden und Knochen. Bei positiven Verl\u00e4ufen sind die meisten Dysfunktionen reversibel; die kompromittierte Knochenstabilit\u00e4t kann sich nur z\u00f6gerlich erholen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003348","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T06:00:35Z","timestamp":1572415235000},"page":"899-904","source":"Crossref","is-referenced-by-count":7,"title":["Endokrine Folgen der Anorexia nervosa"],"prefix":"10.1024","volume":"108","author":[{"given":"Gabriella","family":"Milos","sequence":"first","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich, Klinik f\u00fcr                     Konsiliarpsychiatrie und Psychosomatik, Zentrum f\u00fcr Essst\u00f6rungen,                     Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Hebebrand","sequence":"additional","affiliation":[{"name":"LVR-Klinikum, Kliniken\/Institut der Universit\u00e4t Duisburg-Essen;                     Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und                     Jugendalters, Essen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00356-9"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1073"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22501"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.28.3.381"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.00769"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000365"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.175"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121402"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70180-3"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.12.3127S"},{"key":"c12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.chc.2008.07.002","volume":"18","author":"Muller TD","year":"2009","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"c13","volume":"36","author":"Viltart O","year":"2018","journal-title":"Horm Mol Biol Clin Investig"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0264"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5450.125"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.08.004"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.12.010"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00271"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.12.041"},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.046011"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000771"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00102-1"},{"key":"c23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2855"},{"key":"c24","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-168"},{"key":"c25","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11585"},{"key":"c26","doi-asserted-by":"publisher","DOI":"10.1159\/000443735"},{"key":"c27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0723"},{"key":"c28","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.05.004"},{"key":"c29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1046"},{"key":"c30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1878"},{"key":"c31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0912024"},{"key":"c32","unstructured":"AWMF online.                         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S3-Leitlinie                             \u00abDiagnostik und Therapie von Essst\u00f6rungen\u00bb.                         https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/051-026.html;                         letzter Zugriff: 28.08.2019."},{"key":"c33","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22483"},{"key":"c34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412203112503"},{"key":"c35","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1759-2"},{"key":"c36","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00063"},{"key":"c37","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0039"},{"key":"c38","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.447"},{"key":"c39","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4105"},{"key":"c40","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22451"},{"key":"c41","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.01.008"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T03:09:48Z","timestamp":1615950588000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":41,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1024\/1661-8157\/a003348"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003348","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}