{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:40:42Z","timestamp":1792035642347,"version":"4.4.0"},"reference-count":19,"publisher":"Hogrefe Publishing Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p> Zusammenfassung. Die Lactatazidose ist eine relativ h\u00e4ufig angetroffene klinische Entit\u00e4t im intensivmedizinischen Alltag. Hierbei sind die biochemischen Grundlagen unzureichend verstanden, was zu diversen Missverst\u00e4ndnissen f\u00fchrt. Lactat ist ein physiologischerweise st\u00e4ndig produzierter, wichtiger Energietr\u00e4ger im menschlichen Organismus und keineswegs ein metabolisches \u00abAbfallprodukt\u00bb. Lactat als konjugierte Base der Milchs\u00e4ure entsteht direkt aus Pyruvat, wobei die zugrundeliegende Reaktion H<jats:sup>+<\/jats:sup> verbraucht und damit nicht f\u00fcr die begleitende Azidose verantwortlich sein kann. Eine Lactaterh\u00f6hung per se l\u00e4sst keine R\u00fcckschl\u00fcsse auf die zugrundeliegenden Pathomechanismen zu, insbesondere ist Lactat kein ad\u00e4quater Marker f\u00fcr Sauerstoffmangel und ist nicht daf\u00fcr geeignet, die Gewebeoxygenierung kritischer Patientinnen und Patienten zu steuern. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003508","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T03:30:27Z","timestamp":1600227027000},"page":"979-983","source":"Crossref","is-referenced-by-count":2,"title":["Die Lactatazidose und andere Missverst\u00e4ndnisse"],"prefix":"10.1024","volume":"109","author":[{"given":"Lukas","family":"Baumann","sequence":"first","affiliation":[{"name":"Innere Medizin, Kantonsspital Olten"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Studhalter","sequence":"additional","affiliation":[{"name":"Intensivmedizin und Intermediate Care,                     Kantonsspital Olten"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.12.006"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3689"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000235208.77450.15"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09458-6"},{"key":"c5","volume-title":"Lehninger principles of biochemistry","volume":"7","author":"Nelson DL","year":"2017"},{"key":"c6","unstructured":"Melkonian EA,                                 Schury MP:                         Biochemistry, anaerobic glycolysis. In:                         StatPearls. Treasure Island                         (FL): StatPearls                     Publishing; 2019. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK546695\/; letzter                         Zugriff: 12.05.2020."},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00114.2004"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01506.2010"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1925.143.4-6.243"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-017-3795-6"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0503-3"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71045-X"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.073296"},{"key":"c14","first-page":"1391","volume":"1983","author":"Hochachka P","journal-title":"Science"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00641.2004"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(91)91642-5"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00225.2005"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00475.2007"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00016.2017"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T12:29:48Z","timestamp":1681475388000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1024\/1661-8157\/a003508"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003508","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}