{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T15:47:16Z","timestamp":1649087236031},"reference-count":14,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p> Zusammenfassung. Die Riesenzellarteriitis (RZA) ist die h\u00e4ufigste Vaskulitis bei Patienten \u00fcber 50 Jahre. Betroffen sind die mittelgrossen und grossen Arterien. Unterschieden werden die kraniale und die extrakraniale Form. Dementsprechend k\u00f6nnen die Symptome von Kopfschmerzen, Sehst\u00f6rungen und Kieferclaudicatio bis hin zu Allgemeinsymptomen wie Abgeschlagenheit, polymyalgischen Beschwerden und Fieber reichen. Kritisch ist vor allem die Beteiligung der Augenarterien mit drohendem irreversiblem Visusverlust, weshalb eine rasche Diagnostik und Therapieeinleitung wichtig sind. Es gibt zwar Empfehlungen, aber keine einheitlichen Richtlinien, wie eine RZA diagnostiziert werden soll. Glukokortikoide sind seit 60 Jahren und auch weiterhin die Therapie der Wahl, jedoch sind Nebenwirkungen h\u00e4ufig. Inzwischen konnte belegt werden, dass Tocilizumab eine effiziente Behandlung mit besserer Wirksamkeit und Sicherheit darstellt. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003667","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T07:06:29Z","timestamp":1619593589000},"page":"285-292","source":"Crossref","is-referenced-by-count":0,"title":["CME: Riesenzellarteriitis"],"prefix":"10.1024","volume":"110","author":[{"given":"Katrin","family":"Reiner","sequence":"first","affiliation":[{"name":"Innere Medizin, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fehr","sequence":"additional","affiliation":[{"name":"Innere Medizin, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Wick","sequence":"additional","affiliation":[{"name":"Innere Medizin, Kantonsspital Graub\u00fcnden, Chur"},{"name":"Rheumatologie, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex424"},{"key":"c2","unstructured":"Winkler A,                                 True D.                         Giant cell arteritis: 2018 review. Mo Med.                         2018; 115(5):                         468\u2013470."},{"key":"c3","first-page":"19e23","volume":"9","author":"Sait MR","year":"2017","journal-title":"Int J SurgOpen"},{"key":"c4","first-page":"w14661","volume":"148","author":"Berger CT","year":"2018","journal-title":"Swiss Med Wkly"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1177\/2040622317700089"},{"key":"c6","first-page":"1129","volume":"33","author":"Arend WP","year":"1990","journal-title":"The American College of Rheumatology"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212649"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215672"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1002\/art.22163"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1002\/art.22754"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00560-2"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1002\/art.21699"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202408"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T07:08:29Z","timestamp":1619593709000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1024\/1661-8157\/a003667"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003667","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}