{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:09:51Z","timestamp":1648796991771},"reference-count":19,"publisher":"Hogrefe Publishing Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p> Zusammenfassung. Disulfiram (Antabus\u00ae) wird als Aversiv-Therapeutikum zur R\u00fcckfallprophylaxe bei Alkoholabh\u00e4ngigkeit eingesetzt. Gleichzeitiger Alkoholkonsum kann eine Disulfiram-Ethanol-Reaktion (DER) mit mildem bis schwerem vegetativem Symptomkomplex ausl\u00f6sen. Die Antizipation einer solchen Reaktion soll bei den Betroffenen Alkoholkonsum vermeiden, eine fehlende Abstinenz kann jedoch lebensbedrohlich werden. Rasches Erkennen einer DER im klinischen Alltag, umgehendes Monitoring und supportive Therapie sind angesichts einer fehlenden Antidot-Therapie entscheidend. Ziel dieses Beitrags ist es, das klinische Bild, eine angemessene Differenzialdiagnostik und eine Entscheidungsgrundlage bez\u00fcglich therapeutischem Einsatz von Disulfiram aufzuzeigen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003691","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T09:32:01Z","timestamp":1625650321000},"page":"479-487","source":"Crossref","is-referenced-by-count":0,"title":["CME: Disulfiram-Ethanol-Reaktion (DER): erkennen und                     verhindern"],"prefix":"10.1024","volume":"110","author":[{"given":"Luzia","family":"H\u00fcsser","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Notfallmedizin, Universit\u00e4tsspital                     Z\u00fcrich, Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Eis","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Notfallmedizin, Universit\u00e4tsspital                     Z\u00fcrich, Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","first-page":"1472","volume":"109","author":"Williams E","year":"1937","journal-title":"JAMA"},{"key":"c2","unstructured":"Gupta A.                         Disulfiram and disulfiramlike reactions. In:                         L Nelson,                                 M Howland,                                 N Lewin,                                 S Smith,                                 L Goldfrank,                                 R Hoffma,                         editors. Goldfrank\u2019s Toxicologic                             Emergencies. 11 ed.                         New York; McGraw-Hill                         Education.                         2019;1172\u20131177."},{"key":"c3","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-32-9876-7","volume-title":"Disulfiram. Its use in alcohol dependence and other disorders","author":"De Sousa A","year":"2019"},{"key":"c4","first-page":"47","volume":"16","author":"R\u00f6sner S","year":"2014","journal-title":"Suchtmed"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-015-4339-0"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.4414\/smf.2016.02626"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000222512.25649.08"},{"key":"c8","unstructured":"Center for Substance Abuse\n                        Treatment. TIP                         Series \u2013 Treatment Improvement Protocols (TIPS). Incorporating                         alcohol pharmacotherapies into medical practice (TIP 49).                         2009; (SMA) 09\u20134380.                         Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK64041\/."},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103592"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087366"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2019.1708091"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200701000-00007"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960160514"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-006-0493-8"},{"key":"c15","first-page":"757","volume":"115","author":"Standl T","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1007\/s10049-016-0151-z"},{"key":"c17","unstructured":"Kiefer F,                                 Schuster R,                                 M\u00fcller C,                                 Mann K,                                 Heinz A.                         Alkoholabh\u00e4ngigkeit. In: U. Voderholzer,                                 F. Hohagen,                         Hrsg. Therapie psychischer Erkrankungen                             \u2013 State of the Art 2021. M\u00fcnchen;                         Elsevier\/Urban & Fischer:                         2021;45\u201359."},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-016-0133-x"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-020-00954-5"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T09:33:13Z","timestamp":1625650393000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1024\/1661-8157\/a003691"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003691","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}