{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:56:11Z","timestamp":1648803371355},"reference-count":22,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Zusammenfassung. Bei der Trigeminusneuralgie kommt es zu kurzen neuropathischen Schmerzen im Versorgungsgebiet des Nervus trigeminus. Unterschieden werden eine klassische, eine symptomatische, und eine idiopathische Trigeminusneuralgie. F\u00fcr die Akutbehandlung gibt es nur wenige Medikamente. In der vorgestellten Fallserie berichten wir von f\u00fcnf Personen mit einer Trigeminusneuralgie unterschiedlicher Genese, die gut auf die Behandlung mit Brivaracetam ansprachen. Brivaracetam bindet an das synaptische Vesikelprotein 2A, das auch an Nerven und Nervenwurzeln vorkommt. SV2 reguliert die exozytotische Freisetzung von Neurotransmittern, was die Wirkung von Brivaracetam auf neuropathische Schmerzen erkl\u00e4ren k\u00f6nnte. Der Einsatz von Brivaracetam kann bei der kurzfristigen Therapie von paroxysmalen Schmerzen im Rahmen der Trigeminusneuralgie hilfreich sein. Es sind weitere Studien erforderlich, um diese Wirkung nachzuweisen und einen Placeboeffekt auszuschliessen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003758","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:05:58Z","timestamp":1641369958000},"page":"21-25","source":"Crossref","is-referenced-by-count":0,"title":["Brivaracetam \u2013 eine gute Alternative in der akuten Behandlung der                Trigeminusneuralgie"],"prefix":"10.1024","volume":"111","author":[{"given":"Katharina","family":"Kneppe","sequence":"first","affiliation":[{"name":"Departement f\u00fcr Medizin, Neurologie, Spital Linth, Uznach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Czell","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Medizin, Neurologie, Spital Linth, Uznach"},{"name":"Neurologen am Greifensee, Uster"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416687280"},{"key":"c3","unstructured":"F\u00f6rderreuther S  . et al., Trigeminusneuralgie,\n                  S1-Leitlinie, 2012, in: Deutsche Gesellschaft\n                  f\u00fcr Neurologie (Hrsg.), Leitlinien\n                  f\u00fcr Diagnostik und Therapie in der Neurologie.\n                  Online:  www.dgn.org\/leitlinien; letzter Zugriff:\n               24.05.2021."},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1159\/000110284"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0969-0"},{"key":"c6","first-page":"4235724","author":"Ravichandran A","year":"2019","journal-title":"Case Rep Neurol Med"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003481"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666191010094350"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1111\/head.13963"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00269-X"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1359260"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308208101"},{"key":"c14","first-page":"2150","volume":"90","author":"Bajjalieh SM","year":"1993","journal-title":"Sci"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05223.1994"},{"key":"c16","first-page":"15268","volume":"96","author":"Crowder KM","year":"1999","journal-title":"Sci"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81046-6"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2699-05.2006"},{"key":"c19","first-page":"C960","volume":"299","author":"Nowack A","year":"2010","journal-title":"Physiol"},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01743.x"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-020-01001-z"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.3.361"}],"container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157\/a003758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T08:53:07Z","timestamp":1641977587000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157\/a003758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1024\/1661-8157\/a003758"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157\/a003758","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}