{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T04:33:16Z","timestamp":1679718796262},"reference-count":43,"publisher":"Hogrefe Publishing Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p> Zusammenfassung. Das Spektrum der Optionen zur Behandlung der Herzinsuffizienz mit reduzierter Auswurffraktion (Heart Failure with reduced Ejection Fraction, HFrEF) hat sich in den vergangenen Jahren deutlich erweitert. Die nun publizierten Leitlinien von 2021 der Europ\u00e4ischen Gesellschaft f\u00fcr Kardiologie haben einen neuen Therapie-Algorithmus f\u00fcr Personen mit HFrEF und damit den Stellenwert der verschiedenen Medikamente und Interventionen definiert. Neu ist eine Basistherapie bestehend aus vier Medikamenten mit unterschiedlichen Wirkmechanismen f\u00fcr alle Menschen mit HFrEF indiziert: ein ACE-Hemmer (Angiotensin-Converting Enzyme Inhibitor), ein Betablocker, ein Mineralokortikoid-Rezeptor-Antagonist und ein SGLT-2-Hemmer (Sodium Glucose Co-Transporter-2 Inhibitor). Weitere Massnahmen sollen in Abh\u00e4ngigkeit vom Ansprechen auf diese maximal auftitrierte 4-S\u00e4ulen-Basistherapie und vom Ph\u00e4notyp diskutiert und angewendet werden. Im vorliegenden Artikel diskutieren wir die verf\u00fcgbaren Medikamente und Interventionen, deren Stellenwert im Behandlungsalgorithmus und relevante praktische Aspekte der modernen HFrEF-Therapie. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003876","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T07:01:42Z","timestamp":1654671702000},"page":"445-456","source":"Crossref","is-referenced-by-count":0,"title":["Therapie der Herzinsuffizienz mit reduzierter Auswurffraktion: Was ist                neu in den Leitlinien 2021?"],"prefix":"10.1024","volume":"111","author":[{"given":"Micha T.","family":"Maeder","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Kantonsspital St. Gallen, St. Gallen,                   Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Rickli","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Kantonsspital St. Gallen, St. Gallen,                   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