{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:59:06Z","timestamp":1760043546693},"reference-count":26,"publisher":"Hogrefe Publishing Group","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Zusammenfassung. Nicht-steroidale Antirheumatika (NSAR) geh\u00f6ren zu den am meisten eingenommenen Medikamenten weltweit, wobei eine \u00e4rztliche Rezeptierung und Kontrolle dabei meistens fehlen. Neben bekannten gastrointestinalen und renalen NSAR-Nebenwirkungen werden die h\u00e4ufig auftretenden kardiovaskul\u00e4ren Risiken oftmals vernachl\u00e4ssigt. Nicht-selektive NSAR, aber auch selektive COX-2-Hemmer, inhibieren unter anderem Prostacyclin, das thrombozytenhemmend und vasodilatierend wirkt. Bei den selektiven COX-2-Inhibitoren kommt es zudem zu einer Verschiebung Richtung COX-1-Aktivit\u00e4t, wodurch mehr Thromboxan gebildet wird, was zus\u00e4tzlich zu einer Erh\u00f6hung des Risikos f\u00fcr eine Thrombozytenaggregation f\u00fchrt. Durch eine lange Halbwertszeit charakterisierte, nicht-selektive NSAR zeichnen sich durch stabile Plasmaspiegel und eine stabile Thrombozytenaggregationshemmung aus. Nicht-selektive NSAR vermindern zus\u00e4tzlich auch die Bindung von Acetylsalicyls\u00e4ure an die Thrombozyten und beeintr\u00e4chtigen dadurch deren Wirkung. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003948","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:01:48Z","timestamp":1672819308000},"page":"16-21","source":"Crossref","is-referenced-by-count":2,"title":["Nicht-steroidale Antirheumatika und kardiovaskul\u00e4res                Risiko"],"prefix":"10.1024","volume":"112","author":[{"given":"Christian","family":"Schmied","sequence":"first","affiliation":[{"name":"Kardiologische Poliklinik, Universit\u00e4res Herzzentrum Z\u00fcrich,                Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","unstructured":"Dydyk A , \n                     Yarrarapu SNS , \n                     Conermann T  .  Chronic pain . https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553030\/. 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