{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:17:42Z","timestamp":1779311862445,"version":"3.51.4"},"reference-count":24,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2023,1]]},"abstract":" Zusammenfassung. Die koronare Mikrozirkulationsst\u00f6rung weist insbesondere bei Frauen ab dem f\u00fcnfzigsten Lebensjahr eine hohe Pr\u00e4valenz auf und f\u00fchrt sowohl zu pektangin\u00f6sen Symptomen wie auch zu einer erh\u00f6hten Rate kardiovaskul\u00e4rer Ereignisse. Durch die auch heutzutage noch bestehende Unterdiagnostizierung haben viele Patientinnen und Patienten einen langen Leidensweg hinter sich. Mit einer invasiven Koronarangiografie, die sowohl eine Messung der koronaren Flussreserve wie auch eine Acetylcholin-Provokationstestung beinhaltet, kann die Diagnose einer koronaren Mikrozirkulationsst\u00f6rung gestellt werden. Dies ist einerseits f\u00fcr das Wohl der Patientinnen und Patienten wichtig, erm\u00f6glicht andererseits aber auch eine gezielte Therapie. Diese besteht aus Lebensstilver\u00e4nderungen, einer optimalen Kontrolle kardiovaskul\u00e4rer Risikofaktoren sowie spezifischen anti-angin\u00f6sen Medikamenten. Die aktuelle Forschung versucht, pathophysiologische Mechanismen besser zu verstehen und verbesserte oder alternative diagnostische Verfahren und neue Therapiekonzepte zu entwickeln. <\/jats:p>","DOI":"10.1024\/1661-8157\/a003956","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:01:48Z","timestamp":1672819308000},"page":"22-27","source":"Crossref","is-referenced-by-count":1,"title":["Angina pectoris und die Bedeutung der koronaren Mikrozirkulation in der Praxis"],"prefix":"10.1024","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-1062","authenticated-orcid":false,"given":"Julia","family":"Stehli","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Universit\u00e4tsspital Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-7541","authenticated-orcid":false,"given":"Alessandro","family":"Candreva","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Universit\u00e4tsspital Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-6407","authenticated-orcid":false,"given":"Barbara E.","family":"St\u00e4hli","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, Universit\u00e4tsspital Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"crossref","unstructured":"GBD 2017. 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