{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:09:33Z","timestamp":1747174173071,"version":"3.40.5"},"reference-count":28,"publisher":"Hogrefe Publishing Group","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p> Zusammenfassung: Viele Ursachen einer Zirrhose sind modifizierbar. Daher soll \u00e4tiologisch abgekl\u00e4rt werden. Nach Diagnosesicherung wird die Grundkrankheit behandelt und die Betroffenen werden beraten (Alkoholabstinenz, Rauchstopp, gesunde Ern\u00e4hrung, Impfungen, k\u00f6rperliche Bet\u00e4tigung). Zum Varizenscreening wird eine Gastroskopie empfohlen. Patientinnen und Patienten mit Leberzirrhose haben ein erh\u00f6htes Risiko f\u00fcr hepatozellul\u00e4re Karzinome, deshalb sollten sie halbj\u00e4hrlich eine Lebersonografie und die Bestimmung des Tumormarkers alpha-Foetoprotein machen (HCC Surveillance). Nach erster Dekompensation (z.B. Varizenblutung, Aszites, Enzephalopathie) oder Verschlechterung der Leberfunktion sollte eine Listung zur Lebertransplantation evaluiert werden. Die Kontrollh\u00e4ufigkeit richtet sich nach Krankheitsstadium und eingetretenen Dekompensationen. Viele Komplikationen (z.B. Varizenblutung, spontan bakterielle Peritonitis, akutes Nierenversagen unter NSAR oder Diuretika) beginnen oligosymptomatisch und k\u00f6nnen rasch zu Multiorganversagen f\u00fchren. Daher sollte bei Verschlechterung von Allgemeinzustand, Kognition oder Laborbefunden niedrigschwellig eine rasche Diagnostik erfolgen. <\/jats:p>","DOI":"10.1024\/1661-8157\/a004042","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:01:57Z","timestamp":1686121317000},"page":"373-380","source":"Crossref","is-referenced-by-count":0,"title":["CME: Ambulantes Management von Patientinnen und Patienten mit                Leberzirrhose"],"prefix":"10.1024","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-5825","authenticated-orcid":true,"given":"Florian","family":"Deuschle","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Allgemeine Innere Medizin\/Hausarztmedizin und                Notfallmedizin, Kantonsspital St. Gallen, St. Gallen, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-743X","authenticated-orcid":true,"given":"David","family":"Semela","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie und Hepatologie, Kantonsspital St.                Gallen, St. Gallen, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-6509","authenticated-orcid":true,"given":"Samuel","family":"Henz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemeine Innere Medizin\/Hausarztmedizin und                Notfallmedizin, Kantonsspital St. Gallen, St. Gallen, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","first-page":"85","volume":"110","author":"Wiegand J","year":"2013","journal-title":"Dtsch Arztebl Int"},{"doi-asserted-by":"publisher","key":"c2","DOI":"10.3390\/cells9051212"},{"doi-asserted-by":"publisher","key":"c3","DOI":"10.1016\/S0140-6736(08)60383-9"},{"unstructured":"Bacon BR  . Leberzirrhose und ihre Komplikationen. Muche M,\n                  Somasundaram R, translators. In:  \n                     Longo D , \n                     Fauci A , \n                     Kasper D , \n                     Hauser S , \n                     Jameson J , \n                     Loscalzo J  , editors. Harrisons Innere\n                     Medizin, Band 3. 18th ed. 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