{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:35:55Z","timestamp":1694637355126},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:p> Die autosomal dominante polyzystische Nierenerkrankung (autosomal dominant polycystic kidney disease, ADPKD) ist charakterisiert durch eine massive Vergr\u00f6sserung beider Nieren, bedingt durch unz\u00e4hlige Zysten. Die Zystenbildung beginnt bereits in utero und das kontinuierliche Zystenwachstum f\u00fchrt zur Kompression und Zerst\u00f6rung des nicht-zystischen Nierenparenchyms, sodass schliesslich ein Nierenersatz in der 5. bis 6. Lebensdekade notwendig wird. Bisher gab es keine kausale Therapie, welche das Fortschreiten der Krankheiten aufh\u00e4lt. Tierexperimentelle Daten zeigen, dass die medikament\u00f6se Inhibition eines zentralen Regulators der Zellproliferation, dem so genannten \u00abmammalian target of rapamycin\u00bb (mTOR), den Kranheitsverlauf der ADPKD verlangsamen kann. Die vorliegende \u00dcbersicht vermittelt einen Einblick in die Erkrankung und in die neue therapeutische M\u00f6glichkeit des mTOR Inhibitors Sirolimus, welcher zurzeit in klinischen Studien getestet wird. <\/jats:p>","DOI":"10.1024\/1661-8157.98.25.1511","type":"journal-article","created":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T03:31:29Z","timestamp":1260934289000},"page":"1511-1516","source":"Crossref","is-referenced-by-count":0,"title":["Rapamycin: eine neue Therapieoption bei autosomal dominanter polyzystischer Nierenerkrankung (ADPKD)?"],"prefix":"10.1024","volume":"98","author":[{"family":"Serra","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Nephrologie, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"W\u00fcthrich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nephrologie, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/1661-8157.98.25.1511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:07:06Z","timestamp":1652004426000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/1661-8157.98.25.1511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,1]]},"references-count":0,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2009,12,1]]}},"alternative-id":["10.1024\/1661-8157.98.25.1511"],"URL":"https:\/\/doi.org\/10.1024\/1661-8157.98.25.1511","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,1]]}}}