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The representation of microphysical processes in models continues to pose a major challenge leading to uncertainty in numerical weather forecasts and climate simulations. In this paper, the problem of treating microphysics in models is divided into two parts: (i) how to represent the population of cloud and precipitation particles, given the impossibility of simulating all particles individually within a cloud, and (ii) uncertainties in the microphysical process rates owing to fundamental gaps in knowledge of cloud physics. The recently developed Lagrangian particle\u2010based method is advocated as a way to address several conceptual and practical challenges of representing particle populations using traditional bulk and bin microphysics parameterization schemes. For addressing critical gaps in cloud physics knowledge, sustained investment for observational advances from laboratory experiments, new probe development, and next\u2010generation instruments in space is needed. Greater emphasis on laboratory work, which has apparently declined over the past several decades relative to other areas of cloud physics research, is argued to be an essential ingredient for improving process\u2010level understanding. More systematic use of natural cloud and precipitation observations to constrain microphysics schemes is also advocated. Because it is generally difficult to quantify individual microphysical process rates from these observations directly, this presents an inverse problem that can be viewed from the standpoint of Bayesian statistics. Following this idea, a probabilistic framework is proposed that combines elements from statistical and physical modeling. Besides providing rigorous constraint of schemes, there is an added benefit of quantifying uncertainty systematically. Finally, a broader hierarchical approach is proposed to accelerate improvements in microphysics schemes, leveraging the advances described in this paper related to process modeling (using Lagrangian particle\u2010based schemes), laboratory experimentation, cloud and precipitation observations, and statistical methods.\n                  <\/jats:p>","DOI":"10.1029\/2019ms001689","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T07:47:08Z","timestamp":1589183228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":405,"title":["Confronting the Challenge of Modeling Cloud and Precipitation Microphysics"],"prefix":"10.1029","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-9787","authenticated-orcid":false,"given":"Hugh","family":"Morrison","sequence":"first","affiliation":[{"name":"National Center for Atmospheric Research  Boulder CO 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