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This framework is applied to the city of Medell\u00edn in the Aburr\u00e1 Valley in Colombia. To assess population exposure to particulate matter, numerical simulations, mobility and toxicity data were integrated. The LOTOS\u2010EUROS Chemical Transport Model, driven by the Weather Research and Forecasting (WRF) model, was used to simulate air quality at a spatial resolution of 1\u00a0km\u00a0\u00a01\u00a0km for the year 2019. Mobility dynamics were derived from the Origin\u2010Destination Survey (ODS), comprising over 180,000 trips across 240 traffic analysis zones. The utilisation of this data set facilitated the estimation of time\u2010weighted exposure levels for diverse demographic groups during weekdays. The morpho\u2010chemical properties of the particulate matter samples were analyzed to determine the presence of metals and carbonaceous fractions due to significant health implications. The exposure model is a weighted model that integrates exposure time,  and  concentration, and cytogenotoxic indicators. The application of cluster analysis to the available data, resulted in the identification of areas of elevated health risk, indicating that the central and southern zones, approximately 60% of the metropolitan population and main highway corridors, exhibited mean particulate matter exposure levels that exceeded 40\u00a0\u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    during peak hours, thus surpassing the WHO air quality guidelines. These zones demonstrated the highest levels of exposure, as indicated by cluster significance levels, suggesting more epidemiological studies and public health interventions.\n                  <\/jats:p>","DOI":"10.1029\/2025gh001621","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:29:19Z","timestamp":1784791759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modeling Patterns of Population Exposure With a Multiscale Framework Utilizing LOTOS\u2010EUROS Chemical Transport Model, Mobility Surveys and Particulate Toxicity"],"prefix":"10.1029","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2241-9550","authenticated-orcid":false,"given":"Valeria","family":"Sol\u00f3rzano\u2010Araque","sequence":"first","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"},{"name":"Facult\u00e9 des Sciences et Technologies Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-2367","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Yarce Botero","sequence":"additional","affiliation":[{"name":"Barcelona Supercomputing Center  Barcelona Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-8961","authenticated-orcid":false,"given":"Jhon Edinson","family":"Hinestroza\u2010Ramirez","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"},{"name":"Grupo de Investigaciones Pedag\u00f3gicas en el \u00c1rea de las Matem\u00e1ticas (INPEMA) Universidad Tecnol\u00f3gica del Choc\u00f3  Quibd\u00f3 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-0582","authenticated-orcid":false,"given":"Fernando","family":"Fernandez\u2010Restrepo","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-707X","authenticated-orcid":false,"given":"Sebastian Carmona","family":"Estrada","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2561-6951","authenticated-orcid":false,"given":"Pablo Alberto","family":"Osorio\u2010Marulanda","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2351-7665","authenticated-orcid":false,"given":"Lisseth","family":"Cruz\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"},{"name":"Facult\u00e9 des Sciences et Technologies Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-2629","authenticated-orcid":false,"given":"Santiago","family":"Isaza\u2010Cadavid","sequence":"additional","affiliation":[{"name":"Mathematical Modelling Group Universidad EAFIT  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8697-4361","authenticated-orcid":false,"given":"O. 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