{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:26:18Z","timestamp":1762032378659},"reference-count":111,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,7,18]],"date-time":"2002-07-18T00:00:00Z","timestamp":1026950400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>The pancreas is a vital gland of exocrine and endocrine function. It is the target of two main affections: diabetes and pancreatic cancer. We describe the tissue interactions, signaling pathways and intracellular targets that are involved in the emergence of the pancreas primordium and its proliferation, morphogenesis and differentiation. It appears that several genes of developmental relevance have an adult function and are involved in pancreas affections. Embryological experimentation in animals contributed to provide candidate genes for human disease and holds promise for future treatments.<\/jats:p>","DOI":"10.1034\/j.1399-0004.2002.620102.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:30:12Z","timestamp":1047382212000},"page":"14-23","source":"Crossref","is-referenced-by-count":46,"title":["Development and diseases of the pancreas"],"prefix":"10.1111","volume":"62","author":[{"given":"KA","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Grapin\u2010Botton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,18]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.13.1670"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.6.871"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5422.1998"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.21.4243"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1705"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064344"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90042-5"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1275"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06109.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.904601"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.3.983"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/12674"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/12669"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.6.1569"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/385257a0"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0405"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.24.5109"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1642"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6267"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1065"},{"key":"e_1_2_8_22_2","first-page":"25","article-title":"Pbx1 inactivation disrupts pancreas development and in Ipf1\u2010deficient mice promotes diabetes mellitus","volume":"25","author":"Kim SK","year":"2002","journal-title":"Nat Genet"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00340-X"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80562-0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13036"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(00)80075-X"},{"key":"e_1_2_8_27_2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.125.6.1017","article-title":"Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development","volume":"125","author":"Miralles F","year":"1998","journal-title":"Development"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.12.3451"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2000.6550255.x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2621"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2617"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1571"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.3.827"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.6.1445"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81235-0"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.6.1519"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.112.4.1115"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.9.2895"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.2.325"},{"key":"e_1_2_8_40_2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1242\/jcs.107.6.1429","article-title":"Expression of neural cell adhesion molecule (N\u2010CAM) in rat islets and its role in islet cell type segregation","volume":"107","author":"Cirulli V","year":"1994","journal-title":"J Cell Sci"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.11.2317"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<143::AID-GENE13>3.0.CO;2-L"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2447"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/71657"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/23716"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1607"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.846001"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.16.3533"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.12.1817"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.13.1662"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/387406a0"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.18.2323"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/386399a0"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.12.2213"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.24.5533"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12999"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3752"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/371606a0"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.12.1763"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0171"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.7.10.1275"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200008000-00019"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-138"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7469"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-106"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241349398"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2548"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2472"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.12.5311"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.114"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/384455a0"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199801)15:1<15::AID-DIA562>3.0.CO;2-M"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.11.1503"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979035"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/15500"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.224"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.12.8272"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0220"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2864"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14743"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.21.12646"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.3.243"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.14.6247"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1597"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.6.2464"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00806.x"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.12.4445-4454.2000"},{"key":"e_1_2_8_88_2","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1242\/dev.127.13.2883","article-title":"Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function","volume":"127","author":"Gannon M","year":"2000","journal-title":"Development"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7449"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.137.2.395"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/3828"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.8.561"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050410"},{"key":"e_1_2_8_94_2","first-page":"2051","volume-title":"Textbook of Gastroenterology","author":"Mulholland MW","year":"1995"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4905"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2763"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.859401"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/386084a0"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7318"},{"key":"e_1_2_8_100_2","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1101\/gad.14.15.1866","article-title":"Activin receptor patterning of foregut organogenesis","volume":"14","author":"Kim SK","year":"2000","journal-title":"Genes Dev"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2000.0371"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09504.x"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09510.x"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70292-1"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100406"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.7.1873"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.1.33"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.4.5049"},{"key":"e_1_2_8_109_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.507"},{"key":"e_1_2_8_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/86439"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/73079"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058866"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-0004.2002.620102.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-0004.2002.620102.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1399-0004.2002.620102.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T18:57:05Z","timestamp":1697569025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1399-0004.2002.620102.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":111,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1034\/j.1399-0004.2002.620102.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1399-0004.2002.620102.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}