{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:03:06Z","timestamp":1768532586925,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>Background: Neurological impairment is a major source of morbidity and mortality following orthotopic liver transplantation (OLT). We reviewed our experience with neurologic complications among our first 463 consecutive adult OLT recipients.Methods: Between September 1988 and October 1993, 463 adult patients underwent OLT. Data on incidence, time of onset, and outcome of central nervous system (CNS) complications was obtained from patient charts, including autopsy results when available. CNS complications were classified by clinical presentation and by etiology.Results: 93 patients (20.1%) had CNS complications following OLT. Encephalopathy (11.8%) and seizure (8.2%) were the leading complications. The incidence of immunosuppressive drug\u2010related complications was 5.6%; coma, 1.7%; cerebral hemorrhage, 1.5%; central pontine myelinolysis (CPM), 1.2%; stroke, 0.6%; and primary CNS lymphoma, 0.2%. Most CNS events (80%) were encountered in the first month after OLT. In the majority of cases, encephalopathy (70%) and seizure (50%) presented in the first 2 wk. Although most CNS infections occurred early, 2 patients developed tuberculous meningitis more than 1 yr post\u2010OLT. In 12 patients, death was directly related to CNS complications (2.6%).Conclusions: Most CNS complications occur early following OLT but may be seen even after 1 yr. Patients may survive serious neurologic events, such as cerebral hemorrhage, CPM, and meningitis.<\/jats:p>","DOI":"10.1034\/j.1399-0012.2000.140101.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T13:45:51Z","timestamp":1047390351000},"page":"1-7","source":"Crossref","is-referenced-by-count":182,"title":["Central nervous system complications in liver transplant recipients \u2013 incidence, timing, and long\u2010term follow\u2010up"],"prefix":"10.1111","volume":"14","author":[{"given":"David J","family":"Bronster","sequence":"first","affiliation":[]},{"given":"Sukru","family":"Emre","sequence":"additional","affiliation":[]},{"given":"Patrizia","family":"Boccagni","sequence":"additional","affiliation":[]},{"given":"Patricia A","family":"Sheiner","sequence":"additional","affiliation":[]},{"given":"Myron E","family":"Schwartz","sequence":"additional","affiliation":[]},{"given":"Charles M","family":"Miller","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"63","article-title":"Neurologic complications of orthotopic liver transplantation","volume":"61","author":"Bronster DJ","year":"1994","journal-title":"Mount Sinai J Med"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04070.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1226"},{"key":"e_1_2_5_5_2","first-page":"181","article-title":"Neurologic findings in 100 consecutive liver transplant recipients","volume":"40","author":"Rowley HA","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197803000-00003"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90294-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198806000-00011"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30873-9"},{"key":"e_1_2_5_10_2","first-page":"1471","article-title":"Neuropathological findings in autopsies after liver transplantation","volume":"23","author":"Boon AP","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100030912"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427209"},{"key":"e_1_2_5_13_2","first-page":"25","article-title":"The neuropathology of liver transplantation: comparison of main complications in children and adults","volume":"6","author":"Martinez AJ","year":"1993","journal-title":"Modern Path"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.6.815"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040636"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.11.1962"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199408270-00010"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199703270-00020"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310612"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.10.1297"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198903000-00040"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199406000-00010"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","unstructured":"Bronster DJ Boccagni P O'Rourke M Emre S Schwartz M Miller C. 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