{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:19:18Z","timestamp":1768069158205,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,1,11]],"date-time":"2002-01-11T00:00:00Z","timestamp":1010707200000},"content-version":"vor","delay-in-days":528,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>Sensitization to hen\u2019s egg early in life has been proposed as a predictor for respiratory allergic disease during childhood. However, symptomatic egg allergy in infancy has not been studied in this context. In 1989, a cohort of consecutive births was recruited. Data on family history of atopy and environmental factors were collected. At 4\u2003years of age, 1218 children were seen of whom 981 were skin\u2010prick tested with a range of food and aero\u2010allergens. Of the 1218 children, 29 (2.4%) had suffered symptomatic egg allergy (20 during infancy). Egg allergy in infancy was associated with increased respiratory (asthma, rhinitis) allergic disease (odds ratio [OR] 5.0, 95% confidence intervals [CI] 1.1\u201322.3; p\u200a&lt;\u200a0.05) at 4\u2003years of age, with a positive predictive value (PPV) of 55.0%. The addition of infantile eczema to egg allergy increased the PPV to 80% whereas the addition of family history of atopy had no effect. Egg allergy also increased aero\u2010allergen sensitization (OR 6.1, CI 1.1\u201337.5; PPV 61.1%; p\u200a&lt;\u200a0.05). As a predictor for respiratory allergic disease and aero\u2010allergen sensitization, it carried a high specificity but poor sensitivity. Hence, egg allergy in infancy, especially when coexisting with eczema, increases respiratory allergic symptoms and aero\u2010allergen sensitization in early childhood.<\/jats:p>","DOI":"10.1034\/j.1399-3038.2000.00077.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T16:00:09Z","timestamp":1047484809000},"page":"162-167","source":"Crossref","is-referenced-by-count":157,"title":["Egg allergy in infancy predicts respiratory allergic disease by 4\u2003years of age"],"prefix":"10.1111","volume":"11","author":[{"given":"Syed M.","family":"Tariq","sequence":"first","affiliation":[]},{"given":"Sharon M.","family":"Matthews","sequence":"additional","affiliation":[]},{"given":"Eluzai A.","family":"Hakim","sequence":"additional","affiliation":[]},{"given":"Syed H.","family":"Arshad","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,1,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"985","article-title":"Eczema in childhood","volume":"1","author":"Talbot FB","year":"1918","journal-title":"Med Clin N Am"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91199-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1992.tb00035.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91260-F"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00294.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01164.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02053.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01168.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70164-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90077-F"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb03238.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7056.514"},{"key":"e_1_2_6_14_2","unstructured":"GalenRS&GambinoSR.Beyond Normality. New York:John Wiley 1975:929."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1981.tb02171.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1982.tb09525.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb04761.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80390-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70021-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.3.268"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-3038.2000.00077.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-3038.2000.00077.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1399-3038.2000.00077.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:43:46Z","timestamp":1698601426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1399-3038.2000.00077.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1034\/j.1399-3038.2000.00077.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1399-3038.2000.00077.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}