{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:18:59Z","timestamp":1775693939538,"version":"3.50.1"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,6,20]],"date-time":"2002-06-20T00:00:00Z","timestamp":1024531200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Angiogenesis is tightly regulated by pro\u2010 and anti\u2010angiogenic factors. Secreting mast cells are able to induce and enhance angiogenesis via multiple in part interacting pathways. They include mast cell\u2010derived (i) potent pro\u2010angiogenic factors such as VEGF, bFGF, TGF\u2010beta, TNF\u2010alpha and IL\u20108, (ii) proteinases and heparin, that release heparin\u2010binding pro\u2010angiogenic factors lodged on cell surfaces and in the extracellular matrix (ECM), (iii) histamine, VEGF, and certain lipid\u2010derived mediators that induce microvascular hyperpermeability having pro\u2010angiogenic effects, (iv) chemotactic recruitment of monocytes\/macrophages and lymphocytes that are able to contribute with angiogenesis\u2010modulating molecules, (v) activation of platelets that release pro\u2010angiogenic factors, (vi) activation of neighboring stationary non\u2010mast cells, which secrete pro\u2010angiogenic factors, ECM\u2010degrading proteinases and stem cell factor which attracts, mitogenically stimulates and activates mast cells, (vii) auto\u2010 and paracrine stimulation of mast cells by stem cell factor, (viii) recruitment of mast cells by pro\u2010angiogenic factors such as VEGF, bFGF and TGF\u2010beta. As a result of ECM\u2010degradation and changes in the microenvironment following initial mast cell secretion, the mast cell populations may change significantly in number, phenotype and function. In tumor models, mast cells have been shown to play a decisive role in inducing the angiogenic switch which precedes malignant transformation. There is, moreover, strong evidence that mast cells significantly influence angiogenesis and thus growth and progression in human cancers.<\/jats:p>","DOI":"10.1034\/j.1600-0463.2002.100501.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:25:51Z","timestamp":1047353151000},"page":"355-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":288,"title":["Mast cells and angiogenesis"],"prefix":"10.1111","volume":"110","author":[{"given":"Klas","family":"Norrby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,20]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1182\/blood.V94.7.2333.419k30_2333_2342","article-title":"Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c\u2010kit(+), and expresses aminopeptidase","volume":"94","author":"Kirshenbaum AS","year":"1999","journal-title":"Blood"},{"key":"e_1_2_13_3_2","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1182\/blood.V94.7.2390.419k16_2390_2395","article-title":"Matrix metalloproteinase\u20109 production, a newly identified function of mast cell progenitors, is downregulated by c\u2010kit receptor","volume":"94","author":"Tanaka A","year":"1999","journal-title":"Blood"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01284.x"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200001000-00007"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.1.F1"},{"key":"e_1_2_13_7_2","first-page":"298","article-title":"Mast cells in rat gastrointestinal mucosa. 1. Effect of fixation","volume":"66","author":"Enerb\u00e4ck L","year":"1966","journal-title":"Acta path microbiol scand"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1966.66.3.303"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1966.66.3.313"},{"key":"e_1_2_13_10_2","first-page":"391","volume-title":"Mast cell heterogeneity: basic questions and clinical implications.","author":"Bienenstock J","year":"1982"},{"key":"e_1_2_13_11_2","first-page":"81","volume-title":"Mast Cell and Basophil Differentiation and Function in Health and Disease","author":"Miller HRP","year":"1989"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0469"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65634-9"},{"key":"e_1_2_13_14_2","first-page":"1373","article-title":"Expression of mast\u2010cell\u2010specific proteases in tissues of mice studied by in situ hybridization","volume":"150","author":"Jippo T","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64125-9"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.4.1033"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<1022::AID-IMMU1022>3.0.CO;2-1"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90126-Q"},{"key":"e_1_2_13_19_2","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.4049\/jimmunol.162.9.5528","article-title":"Mast cell expression of gelatinases A and B is regulated by kit ligand and TBF\u2010beta","volume":"162","author":"Fang KC","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2645::AID-IMMU2645>3.0.CO;2-1"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00139-2"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)89022-7"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi001988c"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030100225"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065x.2000.917305.x"},{"key":"e_1_2_13_26_2","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.4049\/jimmunol.160.8.4026","article-title":"Induction and enhancement of Fc(epsilon)RI\u2010dependent mast cell degranulation following coculture with activated T cells: dependency on ICAM\u20101\u2010 and leukocyte function\u2010associated antigen (LFA)\u20101\u2010mediated heterotypic aggregation","volume":"160","author":"Inamura N","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8774"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1101-1194"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115853"},{"key":"e_1_2_13_30_2","first-page":"564","article-title":"Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma","volume":"147","author":"Qu Z","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_13_31_2","first-page":"215","article-title":"Human cutaneous mast cells express basic fibroblast growth factor","volume":"72","author":"Reed JA","year":"1995","journal-title":"Lab Invest"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1135"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.4.875"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023829"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.736"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.45.28220"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00775.x"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59953-8_6"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00014.x"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.381"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750065933"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.5026"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.11.2631"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1209"},{"key":"e_1_2_13_45_2","first-page":"2520","article-title":"Anti\u2010angiogenic cues from vascular basement membrane collagen","volume":"60","author":"Colorado PC","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065298"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90200-3"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5435.1926"},{"key":"e_1_2_13_50_2","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.4049\/jimmunol.152.12.5860","article-title":"Transforming growth factor\u2010beta 1 mediates mast cell chemotaxis","volume":"152","author":"Gruber BL","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.7.2488.2488"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00262.x"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219412"},{"key":"e_1_2_13_54_2","first-page":"71","article-title":"Role of mast cells in mitogenesis and angiogenesis in normal tissue and tumour tissue","volume":"89","author":"Norrby K","year":"1993","journal-title":"Adv Biosci"},{"key":"e_1_2_13_55_2","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.4049\/jimmunol.160.10.5053","article-title":"Human mast cells augment fibroblast proliferation by heterotypic cell\u2010cell proliferation and action of IL\u20104","volume":"160","author":"Trautmann A","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889963"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899089"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1994.1019"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00098.x"},{"key":"e_1_2_13_60_2","first-page":"43","article-title":"Mast\u2010cell histamine is angiogenic through receptors for histamine1 and histamine2","volume":"75","author":"S\u00f6rbo J","year":"1994","journal-title":"Int J Exp Pathol"},{"key":"e_1_2_13_61_2","first-page":"87","article-title":"Evidence of a dual role of endogenous histamine in angiogenesis","volume":"76","author":"Norrby K","year":"1995","journal-title":"Int J Exp Pathol"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1997.tb00590.x"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.4.931"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2000.00150.x"},{"key":"e_1_2_13_65_2","first-page":"315","article-title":"Effect of the mast cell activator compound 48\/80 and heparin in angiogenesis in the chick chorioallantoic membrane","volume":"7","author":"Clinton M","year":"1988","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1996.0062"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.00986.x"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5545"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00350-2"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01030.x"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119458"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319306"},{"key":"e_1_2_13_73_2","first-page":"157","volume-title":"Angiogenesis in health and disease","author":"Ashton AW","year":"2001"},{"key":"e_1_2_13_74_2","first-page":"13","volume-title":"Cancer Medicine","author":"Folkman J","year":"2000"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/70928"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01041.x"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.868"},{"key":"e_1_2_13_79_2","first-page":"17","volume-title":"Farbenanlytische Untersuchungen zur Histologie und Klinik des Blutes","author":"Westphal E","year":"1891"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050037"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.16658"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01682.x"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0215(19970729)72:3<385::aid-ijc1>3.0.co;2-l"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900816"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01160-7"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.01517.x"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02977.x"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109099333"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690070"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000115)85:2<171::AID-IJC4>3.0.CO;2-W"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2001.00171.x"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.19402055.x"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500300012954"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666038"},{"key":"e_1_2_13_95_2","first-page":"7298","article-title":"Generation of multiple angiogenesis inhibitors by human pancreatic cancer","volume":"61","author":"Kisker O","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.11.1382"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/35036374"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.14.1075"},{"key":"e_1_2_13_99_2","first-page":"6757","article-title":"Modulation of tumor angiogenesis by stem cell factor.","volume":"60","author":"Zhang W","year":"2000","journal-title":"Cancer Res"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0463.2002.100501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0463.2002.100501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T17:29:19Z","timestamp":1697563759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0463.2002.100501.x"}},"subtitle":["<i>Review article<\/i>"],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1034\/j.1600-0463.2002.100501.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0463.2002.100501.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2002-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}