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This review addresses the phenomenon of activation\u2010induced cell death (AICD) in T lymphocytes, in which activation through the T\u2010cell receptor results in apoptosis. AICD can occur in a cell\u2010autonomous manner and is influenced by the nature of the initial T\u2010cell activation events. It plays essential roles in both central and peripheral deletion events involved in tolerance and homeostasis, although it is likely that different forms of AICD proceed via different mechanisms. For example, while AICD in peripheral T cells is often caused by the induction of expression of the death ligand, Fas ligand (CD95 ligand, FasL), it does not appear to be involved in AICD in thymocytes. This and other mechanisms of AICD are discussed. One emerging model that may complement other forms of AICD involves the inducible expression of FasL by nonlymphoid tissues in response to activated T lymphocytes. Induction of nonlymphoid FasL in this manner may serve as a sensing mechanism for immune cell infiltration, which contributes to peripheral deletion.<\/jats:p>","DOI":"10.1034\/j.1600-065x.2003.00051.x","type":"journal-article","created":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T15:23:56Z","timestamp":1052753036000},"page":"70-81","source":"Crossref","is-referenced-by-count":506,"title":["Activation\u2010induced cell death in T cells"],"prefix":"10.1111","volume":"193","author":[{"given":"Douglas R.","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Droin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pinkoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,12]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00024-7"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/337181a0"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/339625a0"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2531464"},{"key":"e_1_2_12_6_2","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.4049\/jimmunol.144.9.3326","article-title":"Activation\u2010induced cell death in T cell hybridomas is due to apoptosis. 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