{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:26:02Z","timestamp":1762658762795},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":3204,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p> <jats:bold>Background<\/jats:bold>: Immediate\u2010type allergies to bumblebee stings occur infrequently. Previous studies have demonstrated a high degree of cross\u2010reactivity between honeybee venom (HBV) and bumblebee venom (BBV). It has been proposed that venom immunotherapy (VIT) with HBV is a therapeutic alternative for patients with BBV allergy.<\/jats:p><jats:p> <jats:bold>Methods and results<\/jats:bold>: We present two cases of occupational immediate\u2010type allergies to BBV. Although both nonatopic patients had a negative personal history of previous allergic reactions to honeybee sting, specific IgE antibodies and a positive intradermal reaction to HBV were detected. Despite VIT with HBV, the two developed another severe allergic reaction after incidental bumblebee stings. VIT with BBV, using in one patient a rush protocol with escalating doses of 0.01\u2013100 \u03bcg of BBV, was performed. Before and during the VIT, the course of IgE and IgG specific antibodies to BBV was analyzed, demonstrating a significant decrease of BBV\u2010IgE and an increase of BBV\u2010IgG. The effectiveness of the treatment was also proven by an in\u2010hospital sting challenge with a live bumblebee.<\/jats:p><jats:p> <jats:bold>Conclusions<\/jats:bold>: Our data demonstrate that cross\u2010immunotherapies with HBV do not protect BBV\u2010allergic patients sufficiently. We conclude that BBV\u2010allergic patients should be treated with BBV. A \u201crush\u201d VIT with BBV is a safe alternative to a \u201cconventional\u201d protocol.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00202.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:41:59Z","timestamp":1047346919000},"page":"88-91","source":"Crossref","is-referenced-by-count":26,"title":["Successful treatment of occupational allergy to bumblebee venom after failure with honeybee venom extract"],"prefix":"10.1111","volume":"55","author":[{"given":"A.","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"M\u00fcllner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"W\u00fcthrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Insect sting allergy","author":"M\u00fcller UR","year":"1990"},{"key":"e_1_2_6_3_2","volume-title":"Hummeln \u2013 Bestimmen, Ansiedeln, Vermehren, Sch\u00fctzen","author":"Von Hagen E","year":"1994"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01203.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(84)80015-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(62)80470-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03973.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80159-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb00881.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb02660.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90062-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb00690.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2000.00202.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2000.00202.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:59:41Z","timestamp":1698577181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2000.00202.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1034\/j.1398-9995.2000.00202.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2000.00202.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}