{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:20:45Z","timestamp":1758817245993},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":3022,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> In epidemiologic studies, it may be difficult to identify children with bronchial asthma. Since this is the most common chronic respiratory disease in childhood, and its prevalence is still increasing, reliable methods for identification of asthmatic children are required. This study evaluates the use of urinary eosinophil protein X (U\u2010EPX) in epidemiologic studies in identifying atopic and asthmatic children.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> U\u2010EPX was measured in 877 Austrian schoolchildren. The skin prick test (SPT) was performed with eight common aeroallergens, and established questionnaires were used to assess respiratory symptoms.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> Of our cohort, 2.8% reported physician\u2010diagnosed asthma, 5.1% reported wheezing within the last 12 months, and 24.1% were found to be atopic. In children with physician\u2010diagnosed asthma, as well as in atopic children (positive SPT), median U\u2010EPX levels were significantly higher than in healthy subjects (142.8 and 89.6 <jats:italic>vs<\/jats:italic> 63.9\u2003\u00b5g\/mmol creatinine, <jats:italic>P<\/jats:italic>&lt;0.0001 and <jats:italic>P<\/jats:italic>&lt;0.0001, respectively). In addition, perennial sensitization to inhalant allergens resulted in higher U\u2010EPX levels than did seasonal sensitization. The odds ratio for U\u2010EPX levels over the 90th percentile was significantly elevated for asthma, for wheezing, for nocturnal cough, and for breathlessness at exercise, as well as for seasonal and perennial sensitization. Pulmonary function was negatively relatedto U\u2010EPX levels.<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold> Measurement of U\u2010EPX, which can be obtained easily, may be helpful in diagnosing both asthma and atopy in children. However, there is a great overlap between controls and symptomatics, a fact which reduces the sensitivity of U\u2010EPX in determination of the prevalence of asthma in epidemiologic studies.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00528.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:43:51Z","timestamp":1047347031000},"page":"647-652","source":"Crossref","is-referenced-by-count":16,"title":["Urinary eosinophil protein X in children: the relationship toasthma and atopy and normal values"],"prefix":"10.1111","volume":"55","author":[{"given":"E.","family":"Tauber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Halmerbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Frischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"F.","family":"Horak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Veiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Y.","family":"Koller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Studnicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954000"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306030"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950190304"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1183\/09031936.93.06101455","article-title":"Self\u2010reported prevalence of asthma symptoms in Australia, England, Germany and New Zealand: an international comparison using the ISAAC protocol","volume":"6","author":"Pearce N","year":"1993","journal-title":"Eur Respir J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11061324"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.4.1056"},{"key":"e_1_2_6_9_2","first-page":"73","article-title":"Bronchial hyperresponsiveness and epidemiology of bronchial asthma in childhood","volume":"47","author":"Von Mutius E","year":"1993","journal-title":"Pneumologie"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.3.549"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.3.633"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231505"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.5.413"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854194778702937"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70182-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02605.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102275"},{"key":"e_1_2_6_18_2","first-page":"1285","article-title":"Standardisation of spirometry \u2013 1987 update","volume":"2","author":"American Thoracic Society","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.3.764"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.3.609"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00546.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1999.tb04391.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2000.00528.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2000.00528.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:10:48Z","timestamp":1698592248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2000.00528.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1034\/j.1398-9995.2000.00528.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2000.00528.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}