{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:22:43Z","timestamp":1770330163738,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>Bronchial eosinophilic inflammation and bronchial hyperresponsiveness (BHR) are the main features of allergic asthma (AA), but they have also been demonstrated in allergic rhinitis (AR), suggesting a continuity between both diseases. In spite of not fully reproducing natural allergenic exposure, the allergen bronchial provocation test (A\u2010BPT) has provided important knowledge of the pathophysiology of AA. Our aim was to verify the existence of a behavior of AA and AR airways different from the allergen bronchial challenge\u2010induced airway eosinophilic inflammation and BHR changes. We studied a group of 31 mild and short\u2010evolution AA and 15 AR patients, sensitized to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>. The A\u2010BPT was performed with a partially biologically standardized <jats:italic>D. pteronyssinus<\/jats:italic> extract, and known quantities of Der p 1 were inhaled. Peripheral blood (eosinophils and ECP) and induced sputum (percentage cell counts, ECP, albumin, tryptase, and interleukin [IL]\u20105) were analyzed, before and 24 h after A\u2010BPT. Methacholine BHR, assessed before and 32 h after the A\u2010BPT, was defined by M\u2010PD<jats:sub>20<\/jats:sub> values and, when possible, by maximal response plateau (MRP). The A\u2010BPT was well tolerated by all the patients. AA presented a lower Der p 1 PD<jats:sub>20<\/jats:sub> and a higher occurrence of late\u2010phase responses (LPR). M\u2010PD<jats:sub>20<\/jats:sub> values decreased in AA, but not in AR, patients. MRP values increased in both groups. Eosinophils numbers and ECP levels increased in blood and sputum from both AA and AR, but only the absolute increment of sputum ECP levels was higher in AA than AR patients (<jats:italic>P<\/jats:italic>=0.025). The A\u2010BPT induced no change in sputum albumin, tryptase, or IL\u20105 values. We conclude as follows:<\/jats:p><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>In spite of presenting a lower degree of bronchial sensitivity to allergen, AR patients responded to allergen inhalation with an eosinophilic inflammation enhancement very similar to that observed among AA.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MRP levels increased in both AA and AR patients after allergen challenge; however, M\u2010PD<jats:sub>20<\/jats:sub> values significantly changed only in the AA group, suggesting that the components of the airway response to methacholine were controlled by different mechanisms.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is possible that the differences between AR and AA lie only in the quantitative bronchial response to allergen inhalation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00534.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:43:43Z","timestamp":1047347023000},"page":"531-539","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of allergen\u2010induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients"],"prefix":"10.1111","volume":"55","author":[{"given":"M. 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