{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:55:22Z","timestamp":1768478122561,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold>\u2002The role of ash (<jats:italic>Fraxinus excelsior<\/jats:italic>) pollen as a cause of spring pollinosis in central Europe has received little attention. It is not clear whether ash pollen is a primary cause of sensitization or whether it is implicated through cross\u2010sensitization to other pollens.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold>\u2002Over a 22\u2010month period, ash pollen was included in a screening series for inhalant allergies. Pollen data were documented from 1976 through 1999. The frequency of IgE\u2010binding to the ash\u2010specific allergen Fra e 1 and pollen panallergens, respectively, was compared by Western blot between mono\u2010 (<jats:italic>n<\/jats:italic>=6), oligo\u2010 (<jats:italic>n<\/jats:italic>=16), and polysensitized (<jats:italic>n<\/jats:italic>=25) patients.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold>\u2002Of 5416 consecutive patients sensitized to any pollen, 920 (17.6%) had a positive skin prick test to ash. Total pollen counts varied extensively between years (229\u20135351) as did peak concentrations (23\u2013837 grains\/m<jats:sup>3<\/jats:sup>\/24 h). Western blotting revealed Fra e 1 sensitization in 100% of monosensitized, 93% of oligosensitized, but only 44% of polysensitized patients. IgE against profilins (Fra e 2), Ca\u2010binding proteins (Fra e 3), and carbohydrate epitopes in the three groups was found in 0\/0\/17%, 0\/19\/31%, and 32\/72\/60%, respectively. At least 50% of sera from patients with Fra e 1 sensitization did not bind with the protein in Western blots under reducing conditions.<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold>\u2002Ash pollen should be considered a relevant factor and distinct entity in spring pollinosis. In all, only 20% of positive skin tests to ash appear to result from cross\u2010sensitization to pollen panallergens.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00671.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:41:44Z","timestamp":1047346904000},"page":"923-930","source":"Crossref","is-referenced-by-count":60,"title":["Ash (<i>Fraxinus excelsior<\/i>)\u2010pollen allergy in central Europe:specific role of pollen panallergens and the major allergen of ash pollen, Fra e 1"],"prefix":"10.1111","volume":"55","author":[{"given":"W.","family":"Hemmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Focke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wantke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Jarisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1983.tb02624.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90485-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb02074.x"},{"key":"e_1_2_6_5_2","first-page":"318","article-title":"Sensitivity to Olea europaea pollen in different populations in Israel","volume":"26","author":"Geller\u2010Bernstein C","year":"1994","journal-title":"Allerg Immunol (Paris)"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237370"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1984.tb01981.x"},{"key":"e_1_2_6_8_2","first-page":"1150","article-title":"Pollinosis. 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