{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:58:36Z","timestamp":1774123116879,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> Parameters of eosinophil inflammation have been suggested as markers of disease activity in atopic dermatitis (AD), but the value of urinary eosinophil protein X (U\u2010EPX) in children with AD, as well as the influence of allergic sensitization, is not known.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> We measured U\u2010EPX in 59 atopic and 29 nonatopic children with mild (<jats:italic>n<\/jats:italic>=32), moderate (<jats:italic>n<\/jats:italic>=34), and severe (<jats:italic>n<\/jats:italic>=22) AD, as well as in 64 controls.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> U\u2010EPX was increased in children with AD (110; 67\u2013164\u2003\u03bcg\/mmol creatinine, median; quartiles) compared to controls (62; 41\u201395, <jats:italic>P<\/jats:italic>&lt;0.001). Children with mild (97; 63\u2013164, <jats:italic>P<\/jats:italic>&lt;0.01), moderate (108; 67\u2013157, <jats:italic>P<\/jats:italic>&lt;0.01), and severe disease (152; 99\u2013202, <jats:italic>P<\/jats:italic>&lt;0.001) had levels of U\u2010EPX higher than controls. U\u2010EPX was significantly higher in children with severe AD than in mild and moderate disease (<jats:italic>P<\/jats:italic>&lt;0.05 for both). Children with AD and a positive skin prick test (120; 81\u2013176) had higher levels of U\u2010EPX than children with a negative skin prick test (87; 56\u2013155, <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold> U\u2010EPX is significantly increased in children with AD and may reflect disease activity. U\u2010EPX may also reflect differences in eosinophil activation between those sensitized and those not sensitized to common allergens.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00682.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:41:44Z","timestamp":1047346904000},"page":"964-968","source":"Crossref","is-referenced-by-count":17,"title":["Urinary eosinophil protein X in children with atopic dermatitis: relation to atopy and disease activity"],"prefix":"10.1111","volume":"55","author":[{"given":"K.","family":"\u00d8ymar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bjerknes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)12082-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70049-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90347-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb02167.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247419"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00677.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/150.5_Pt_2.S33"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90078-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90087-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(91)90214-Z"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_6_13_2","first-page":"13","article-title":"Grading of the severity of atopic dermatitis","volume":"144","author":"Rajka G","year":"1989","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00731.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237726"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00115.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1994.tb03150.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00542.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70009-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02609.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199803)25:3<167::AID-PPUL6>3.0.CO;2-J"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00666.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1996.tb04038.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70202-7"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01236.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2000.00682.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2000.00682.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T07:50:36Z","timestamp":1698565836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2000.00682.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1034\/j.1398-9995.2000.00682.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2000.00682.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}