{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:24:27Z","timestamp":1789053867697,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":388,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> There are detailed descriptions of the clinical experiences and prescriptions of asthma in traditional Chinese medicine. Xiao\u2010qing\u2010long tang (XQLT), or sho\u2010seiryo\u2010to by its Japanese name, is one of the Chinese herbal medicines used to treat bronchial asthma and allergic rhinitis for centuries. However, the therapeutic mechanisms of this medication are still far from clear. In this study, a house\u2010dust\u2010mite (<jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> [Der p])\u2010sensitized murine model of asthma was used to evaluate the immunomodulatory effect of XQLT on the allergen\u2010induced airway inflammation in asthma.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> Three different protocols were designed to evaluate the treatment and\/or long\u2010term prophylactic effect of XQLT in Der p\u2010sensitized mice. XQLT extracts (1 gm\/kg) were administered to sensitized mice 1\u2003h before allergen challenge (AC) (group A), 24\u2003h after AC (group B), and every other day six times before AC (group C), respectively. Cellular infiltration and T\u2010cell subsets in the bronchoalveolar lavage fluid (BALF) of allergen\u2010challenged mice were analyzed. Intrapulmonary lymphocytes were also isolated to evaluate their response to allergen stimulation.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> When XQLT was administered to the sensitized mice before AC (groups A and C), it suppressed airway inflammation by decreasing the number of total cells and eosinophil infiltration in the BALF, and downregulated the allergen\u2010 or mitogen\u2010induced intrapulmonary lymphocyte response of sensitized mice as compared to those of controls. This immunomodulatory effect of XQLT may be exerted through the regulation of T\u2010cell subsets by elevation or activation of the CD8<jats:sup>+<\/jats:sup> and double\u2010negative T\u2010cell population in the lung. However, the administration of XQLT to sensitized mice 24\u2003h after AC (group B) did not have the same inhibitory effect on the airway inflammation as XQLT given before AC.<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold> The administration of XQLT before AC has the immunomodulatory effect of reducing bronchial inflammation in the allergen\u2010sensitized mice.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2000.00728.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:42:25Z","timestamp":1047346945000},"page":"1127-1133","source":"Crossref","is-referenced-by-count":59,"title":["The effect of Chinese herbal medicine, xiao\u2010qing\u2010long tang (XQLT), on allergen\u2010induced bronchial inflammation in mite\u2010sensitized mice"],"prefix":"10.1111","volume":"55","author":[{"given":"S. T.","family":"Kao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Y.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"63","article-title":"Treatment of childhood asthma with traditional Chinese medicines","volume":"9","author":"Chien L","year":"1986","journal-title":"Bull Beijing Med Coll"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.4044\/joma1947.102.11-12_1323","article-title":"Studies on the treatment for intractable asthma. II. 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