{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:24:42Z","timestamp":1787592282961,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,15]],"date-time":"2002-01-15T00:00:00Z","timestamp":1011052800000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> Cetirizine, an effective H<jats:sub>1<\/jats:sub>\u2010receptor antagonist, is a racemate mixture of two enantiomers: levocetirizine (<jats:italic>R<\/jats:italic> enantiomer) and dextrocetirizine (<jats:italic>S<\/jats:italic> enantiomer).<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> To investigate the pharmacologic activity of the two enantiomers of cetirizine, we conducted a randomized, double\u2010blind, four\u2010way, crossover study to assess the effect of treatment with 5\u2003mg levocetirizine, 5\u2003mg dextrocetirizine, and 10\u2003mg cetirizine and matched placebo, on histamine\u2010induced changes in the nasal airways of 24 healthy volunteers. Four hours after a single oral intake, all subjects were challenged by nasal aerosol application with increasing doubling concentrations (from 0.25 to 32\u2003mg\/ml) of histamine in both nostrils. Nasal resistance was measured by passive anterior rhinomanometry (PAR), and changes in histamine threshold were calculated together with the absolute number of sneezes after each challenge.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> Both levocetirizine and cetirizine significantly attenuated the histamine\u2010induced increase in nasal airway resistance by nearly 50% (from a median resistance of 2.51\u2003Pa per cm<jats:sup>3<\/jats:sup>\/s to 1.29 and 1.31\u2003Pa per cm<jats:sup>3<\/jats:sup>\/s, respectively) at the maximal concentration, and they concomitantly increased the histamine threshold by fourfold (from 8 to 32\u2003mg\/ml), compared with placebo. Sneezing was also attenuated by both levocetirizine and cetirizine. However, these antihistaminic effects were not seen with dextrocetirizine.<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold> This study shows a similar activity of levocetirizine and cetirizine on the inhibition of histamine\u2010induced increase in nasal resistance, indicating that the antihistaminic properties of cetirizine are probably attributable to levocetirizine.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2001.00775.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:46:21Z","timestamp":1047347181000},"page":"339-343","source":"Crossref","is-referenced-by-count":79,"title":["Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine\u2010induced nasal response in healthy adult volunteers"],"prefix":"10.1111","volume":"56","author":[{"given":"D.Y.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hanotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"791","volume-title":"Asthma and rhinitis","author":"Wood\u2010Baker R","year":"1995"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1989.tb02750.x"},{"key":"e_1_2_6_4_2","first-page":"1165","article-title":"Histamine and asthma","volume":"135","author":"White MV","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00019.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00045.x"},{"key":"e_1_2_6_7_2","first-page":"273","volume-title":"Histamine and H1\u2010receptor antagonists in allergic disease","author":"Sim TC","year":"1996"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.0290s3125.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70172-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70307-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63462-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62991-2"},{"key":"e_1_2_6_13_2","first-page":"35","article-title":"Histamine threshold and nasal hyperreactivity in non\u2010specific allergic rhinopathy","volume":"23","author":"Clement PAR","year":"1985","journal-title":"Rhinology"},{"key":"e_1_2_6_14_2","first-page":"263","article-title":"The nasal provocation with histamine: the comparison of the determination of the threshold of the activity by three methods of rhinomanometry","volume":"27","author":"Gordts F","year":"1989","journal-title":"Rhinology"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1995.tb00063.x"},{"key":"e_1_2_6_16_2","first-page":"151","article-title":"Committee report on standardization of rhinomanometry","volume":"22","author":"Clement PAR","year":"1984","journal-title":"Rhinology"},{"key":"e_1_2_6_17_2","first-page":"503","volume-title":"Non\u2010parametric statistical methods","author":"Hollander M","year":"1973"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb00976.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-199809000-00006"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2001.00775.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2001.00775.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:43:25Z","timestamp":1697575405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2001.00775.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1034\/j.1398-9995.2001.00775.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2001.00775.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}