{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:58:06Z","timestamp":1774115886490,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2002,8,8]],"date-time":"2002-08-08T00:00:00Z","timestamp":1028764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Although widely practiced for over 80 years, the role of specific immunotherapy (SIT) in pediatric asthma treatment is still controversial. We assessed the effects of a 3\u2010year period of subcutaneous administration of a standardized preparation of <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> (<jats:italic>D pt<\/jats:italic>) on the respiratory health in a group of asthmatic children monosensitized to house dust mite (HDM).<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> A randomized clinical trial was performed after 1\u2010year run\u2010in period. Fifteen children receiving SIT for HDM and 14 controls (four drop\u2010outs), matched for age, allergen sensitization, asthma severity, lung function, and non\u2010specific bronchial reactivity (BHR), were studied during the 3\u2010year treatment period. During the whole trial, respiratory symptoms, pharmacological and respiratory function parameters were regularly evaluated. Skin prick tests and methacholine challenge were performed at the beginning and end of the study.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> In the SIT group significant improvement in asthmatic symptoms and marked reduction in drug intake was observed. The SIT group also showed a significant decrease in non\u2010specific bronchial BHR. No new sensitivity occurred during the study period in the SIT group only. No major local or systemic side\u2010effects were reported during the study.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Our results confirm that SIT is effective in asthmatic children sensitive to mites. It is associated with a decrease in BHR and it may prevent the development of new sensitizations in monosensitized subjects.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2002.23498.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:50:24Z","timestamp":1047347424000},"page":"785-790","source":"Crossref","is-referenced-by-count":79,"title":["Benefits of immunotherapy with a standardized <i>Dermatophagoides pteronyssinus<\/i> extract in asthmatic children: a three\u2010year prospective study"],"prefix":"10.1111","volume":"57","author":[{"given":"M.","family":"Pifferi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Marrazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ragazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pietrobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Boner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,8]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb01711.x"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1990.tb02389.x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"crossref","unstructured":"MallingH\u2010J WeekeB eds.Position paper: Immunotherapy.Allergy1993;48(S14):9\u201335.","DOI":"10.1111\/j.1398-9995.1993.tb04754.x"},{"key":"e_1_2_13_5_2","first-page":"1","article-title":"Position paper on allergen immunotherapy","volume":"23","author":"members of the working party BSACI","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_13_6_2","volume-title":"Workshop Report. 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