{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:06:02Z","timestamp":1770350762197,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,7,11]],"date-time":"2002-07-11T00:00:00Z","timestamp":1026345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p> <jats:bold>Background:\u2002<\/jats:bold> Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is a potentially fatal inflammatory disease due to the dual\u2010type immune response provoked by the fungal antigens. Despite serious side effects long\u2010term treatment with corticosteroids is often required. Itraconazole has been reported to be a useful steroid\u2010sparing agent.<\/jats:p><jats:p> <jats:bold>Methods:\u2002<\/jats:bold> In a retrospective follow\u2010up of 21 CF patients from a total of 250 treated once or twice within a five\u2010year study period (1994\u201398), 9 patients were treated with systemic glucocorticosteroids in combination with itraconazole and 12 patients were treated with itraconazole (200\u2013600\u2003mg\/day) as monotherapy.<\/jats:p><jats:p> <jats:bold>Results:\u2002<\/jats:bold>\n          During treatment the percentage of \n          <jats:italic>Aspergillus fumigatus<\/jats:italic>\n           (AF)\u2010positive sputum cultures significantly reduced (\n          <jats:italic>P<\/jats:italic>\n          \u2003&lt;\u20030.05); precipitating antibodies to AF decreased significantly in all patients (\n          <jats:italic>P<\/jats:italic>\n          \u2003&lt;\u20030.05); forced expiratory volume (FEV\n          <jats:sub>1)<\/jats:sub> increased to pre\u2010exacerbation level; total IgE levels decreased in 42% of patients on monotherapy and in 56% on combination therapy. Specific IgE (radioallergosorbant; RAST) level decreased in 6 of 21 patients. Eleven patients had transient increased levels of alanine transaminase (ALAT). One patient had isolated increase in alkaline phosphatase and another in aspartate transaminase (ASAT).<\/jats:p><jats:p> <jats:bold>Conclusions:\u2002<\/jats:bold> High dose itraconazole as monotherapy or in combination with systemic glucocorticosteroids seems effective in CF patients with ABPA. No hepatotoxicity was observed during long\u2010term therapy.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2002.23583.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:49:55Z","timestamp":1047347395000},"page":"723-728","source":"Crossref","is-referenced-by-count":44,"title":["Itraconazole treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis"],"prefix":"10.1111","volume":"57","author":[{"given":"M","family":"Skov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"H\u00f8iby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"},{"key":"e_1_2_6_3_2","first-page":"179","article-title":"Allergic bronchopulmonary mycosis complicating cystic fibrosis","volume":"7","author":"Knutsen AP","year":"1992","journal-title":"Semin Respir Infect"},{"key":"e_1_2_6_4_2","first-page":"863","article-title":"Aspergillosis and atopy in cystic fibrosis","volume":"20","author":"Nelson LA","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_5_2","first-page":"105","article-title":"Frequency of Aspergillus fumigatus isolates and antibodies to Aspergillus fumigatus antigens in cystic fibrosis","volume":"93","author":"Sch\u00d8nheyder H","year":"1985","journal-title":"Acta Pathol Microbiol Scand (B)"},{"key":"e_1_2_6_6_2","first-page":"333","article-title":"Allergic broncho\u2010pulmonary aspergillosis in patients with and without evidence of bronchiectasis","volume":"70","author":"Greenberger PA","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234365"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-3-286"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70343-8"},{"key":"e_1_2_6_10_2","first-page":"103","article-title":"Correlates of osteopenia in patients with cystic fibrosis","volume":"97","author":"Bhudhikanok. GS","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.3.813"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.3.883"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62114-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.7.1065"},{"key":"e_1_2_6_15_2","article-title":"Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey. Thesis","volume":"262","author":"H\u00d8iby N","year":"1977","journal-title":"Acta Pathol Microbiol Scand (C)"},{"key":"e_1_2_6_16_2","first-page":"541","article-title":"Epidemiological investi\u2010gations of the respiratory tract in patients with cystic fibrosis","volume":"82","author":"H\u00d8iby N","year":"1974","journal-title":"Acta Pathol Microbiol Scand (B)"},{"key":"e_1_2_6_17_2","first-page":"8","volume-title":"Pulmonary Function Testing in Children: Tech\u2010niques and Standards","author":"Polgar G","year":"1971"},{"key":"e_1_2_6_18_2","first-page":"273","article-title":"Serum antibodies to Aspergillus fumigatus in patients with pulmonary aspergillosis detected by immunofluorescence","volume":"90","author":"Sch\u00d8nheyder H","year":"1982","journal-title":"Acta Pathol Microbiol Scand (B)"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","unstructured":"WojnarowskiC EichlerI GartnerC et al.Sensitisation toAspergillus fumigatusand lung function in children with cystic fibrosis.Am J Respir Crit Care Med;155:1997.","DOI":"10.1164\/ajrccm.155.6.9196093"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.50.1.303"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63157-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.2.525"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.9612044"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.6.1665"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1988.tb03653.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.3.980a"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90042-7"},{"key":"e_1_2_6_28_2","first-page":"352","article-title":"Allergic broncho\u2010pulmonary aspergillosis successfully treated with itraconazole","volume":"35","author":"Matsuzaki Y","year":"1997","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_2_6_29_2","first-page":"781","article-title":"Allergic bronchopulmonary aspergillosis effectively treated with itraconazole","volume":"36","author":"Fujimori Y","year":"1998","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00296.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90244-B"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.2.364"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421102"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401273300407"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/26.4.561"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00716.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00330.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1988.tb02040.x"},{"key":"e_1_2_6_39_2","article-title":"Iatrogenic adrenal insufficiency as side\u2010effects to combined treatment of itraconazole and bridesonide","author":"Skov M","journal-title":"Eur Resp J. In press"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2002.23583.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2002.23583.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:22:43Z","timestamp":1697538163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2002.23583.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,11]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1034\/j.1398-9995.2002.23583.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2002.23583.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,11]]}}}