{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:37:26Z","timestamp":1772131046398,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T00:00:00Z","timestamp":1039564800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A significant proportion of patients diagnosed with cough\u2010variant asthma eventually manifest classic asthma signs, such as wheezing and dyspnea. The aim of this study was to investigate whether the degree of airway hypersensitivity and\/or the level of maximal airway response can predict the development of wheezing in subjects with cough\u2010variant asthma.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> At study initiation, a high\u2010dose methacholine inhalation test was performed to measure provocative concentration causing a 20% fall (PC<jats:sub>20<\/jats:sub>) in forced expiratory volume in 1\u2003s (FEV<jats:sub>1<\/jats:sub>) and maximal airway response. Each person was evaluated regularly every 3\u2003months for 4\u2003years and also on the occasion of wheezing being perceived for the first time.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of the 48 patients available in the follow\u2010up period, 21 (Group\u20031) developed clinical wheezing, while 27 (Group\u20032) did not. There was no significant difference in PC<jats:sub>20<\/jats:sub> levels between the two groups. The level of maximal airway response, however, was significantly higher in Group\u20031 than in Group\u20032. The score test for trend revealed a significant association between the future development of wheezing and the level of maximal airway response (<jats:italic>P<\/jats:italic>\u2003=\u20030.007), but not the level of methacholine PC<jats:sub>20<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2003=\u20030.423).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The level of maximal airway response, rather than the degree of airway hypersensitivity, may be an important risk factor for the future development of classic asthma in patients with cough\u2010variant asthma.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2002.23602.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:48:29Z","timestamp":1047347309000},"page":"1165-1170","source":"Crossref","is-referenced-by-count":22,"title":["The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough\u2010variant asthma"],"prefix":"10.1111","volume":"57","author":[{"given":"Y. Y.","family":"Koh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,11]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"278","article-title":"Cough\u2010type asthma: a review","volume":"66","author":"O ' Connel EJ","year":"1991","journal-title":"Ann Allergy"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198603000-00015"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.640"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903223001201"},{"key":"e_1_2_9_6_2","first-page":"1053","article-title":"Hidden asthma in childhood","volume":"135","author":"Konig P","year":"1981","journal-title":"Am J Dis Child"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.2.206"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.1.2"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90169-X"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.5.671"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90226-5"},{"key":"e_1_2_9_12_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1183\/09031936.93.02030267","article-title":"Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing","volume":"2","author":"Sterk PJ","year":"1989","journal-title":"Eur Respir J"},{"key":"e_1_2_9_13_2","first-page":"71","article-title":"The shape of the dose\u2013response curve to histamine in asthmatic and normal subjects","volume":"130","author":"Woolcock AJ","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9606053"},{"key":"e_1_2_9_15_2","first-page":"25","article-title":"Normal predicted values of pulmonary function test in Korean school\u2010aged children","volume":"36","author":"Yoon KA","year":"1993","journal-title":"J Korean Pediatr Assoc"},{"key":"e_1_2_9_16_2","first-page":"69","article-title":"The seasonal variation of house dust mite allergen and the incidence of bronchial asthma among children","volume":"34","author":"Paik YH","year":"1991","journal-title":"J Korean Med Assoc"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)92143-O"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90107-4"},{"key":"e_1_2_9_19_2","first-page":"714","article-title":"Maximal airway narrowing in humans in vivo: histamine compared with methacholine","volume":"134","author":"Sterk PJ","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70329-X"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90061-5"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2005013"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.685"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14b11.x"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80005-3"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.4.895"},{"key":"e_1_2_9_27_2","first-page":"273","article-title":"Relationship between airway responsiveness and peak expiratory flow variability in subjects with allergic rhinitis","volume":"75","author":"Prieto L","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.7.711"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1398-9995.2002.23602.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1398-9995.2002.23602.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T17:22:10Z","timestamp":1697563330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1398-9995.2002.23602.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1034\/j.1398-9995.2002.23602.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1398-9995.2002.23602.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}