{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:02:13Z","timestamp":1790942533559,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T00:00:00Z","timestamp":1032307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The authors recently assessed the incidence and determinants of immunologic sensitization to flour in apprentice pastry\u2010makers. The aim of this work was to determine the incidence of work\u2010related rhinoconjunctivitis (RC) symptoms and their determinants.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> For this 188\/230 entrants (81.7%) were evaluated before starting exposure to flour, and again 10.8 and 16.8\u2003months after. Questionnaires and skin prick testing to common and work\u2010related allergens were administered at each visit. Bronchial responsiveness to methacholine was assessed at baseline in all subjects and in a subgroup at follow\u2010up.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Thirty subjects (16.1%) reported new work\u2010related RC symptoms (13.1 per 100 person\u2013years); in three subjects (1.6%), these were accompanied by incident skin prick test reactivity to flour\u2010derived allergens. Skin prick test reactivity to grass pollens (OR\u2003=\u20033.0, 95% CI, 1.3\u20136.7) and to pets (OR\u2003=\u20032.5, 95% CI, 1.1\u20135.9), persistent rhinitis (OR\u2003=\u20033.1, 95% CI, 1.1\u20138.4), seasonal RC (OR\u2003=\u20032.5, 95% CI, 1.1\u20135.5), RC on contact with pets (OR\u2003=\u20032.3, 95% CI, 1.03\u20135.0) and skin prick test reactivity to wheat flour (OR\u2003=\u200310.5, 95% CI, 2.3\u201346.8), assessed at baseline, were significantly associated with the incidence of work\u2010related RC symptoms. Multivariate logistic regression analysis yielded significant OR of skin prick test reactivity to wheat flour at baseline (OR\u2003=\u20037.1, 95% CI, 1.7\u201335.1) and persistent rhinitis (OR\u2003=\u20033.9, 95% CI, 1.01\u20139.6) for the incidence of work\u2010related RC symptoms. Increased bronchial hyperresponsiveness at follow\u2010up was more frequent, although not significantly, in subjects positive to skin prick test to flour on entry and reporting new work\u2010related symptoms (3\/5), than in other subjects (4\/17).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The incidence of work\u2010related RC symptoms among apprentice pastry\u2010makers was high (16.1% 30\/186), while a minority (3\/30) also developed skin prick test reactivity to flour. Skin prick test reactivity to wheat flour and persistent allergic rhinitis on starting exposure to flour are significant determinants for the development of work\u2010related RC symptoms.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2002.23636.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:47:56Z","timestamp":1047347276000},"page":"913-918","source":"Crossref","is-referenced-by-count":60,"title":["Incidence and host determinants of work\u2010related rhinoconjunctivitis in apprentice pastry\u2010makers"],"prefix":"10.1111","volume":"57","author":[{"given":"D.","family":"Gautrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ghezzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Infante\u2010Rivard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.","family":"Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,9,18]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199812)34:6<529::AID-AJIM1>3.0.CO;2-I"},{"key":"e_1_2_9_3_2","first-page":"377","volume-title":"Asthma in the workplace","author":"Heederik D","year":"1999"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004200050377"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/50.1.25"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.1.58"},{"key":"e_1_2_9_7_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/annhyg\/45.2.97","article-title":"Allergen and dust exposure as determinants of work\u2010related symptoms and sensitization in a cohort of flour\u2010exposed workers; 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