{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:44:17Z","timestamp":1767339857420},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T00:00:00Z","timestamp":1039564800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The recovery of mediator metabolites from urine has the potential to provide a rapid, safe, and easily available index of release of mediators. We aimed to determine urinary metabolites of both histamine and leukotrienes (LTs) in patients affected by chronic urticaria (CU).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty patients with CU were studied. They were selected on the basis of double\u2010blind placebo\u2010controlled challenge (DBPC) with acetyl salicylic acid (ASA) and food additives. Ten patients (group\u2003B) were negative to both challenges. Ten patients (group\u2003C) presented urticaria and\/or the appearance of angioedema during or 24\u2003h after challenge, with reactions to ASA (five patients) or food additives (five patients). We recruited 15 healthy volunteers as controls (group\u2003A). During a second challenge, groups B and C were challenged double\u2010blind with a single dose of ASA, or a specific food additive, or placebo. The healthy group\u2003was challenged only with a placebo (talc capsule). Patients in groups B and C were challenged twice: with placebo (as groups B1 and C1) and with ASA (groups B2 and C2) or food additives (C2). Four samples of urine were collected; one during the night before the specific or sham challenge (baseline), and three at 2, 6 and 24 h after the challenge. Urinary methylhistamine (N\u2010MH) and LTE<jats:sub>4<\/jats:sub> were analyzed and normalized for urinary creatinine.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> For urinary N\u2010MH at baseline, there was a significant difference only between group\u2003A and groups B1, B2, C1 and C2 (A <jats:italic>vs.<\/jats:italic> B1, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001; A <jats:italic>vs.<\/jats:italic> B2, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001; A <jats:italic>vs.<\/jats:italic> C1, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001; A <jats:italic>vs.<\/jats:italic> C2, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). We detected a significant variation in urinary methylhistamine excretion only in group\u2003C2 after 2\u2003h, 6\u2003h and 24\u2003h (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). However, no variations were observed in N\u2010MH excretion rate in the other groups\u2003(A, B1, C1) after challenge with placebo, and in\u2003B2 after challenge with ASA 20\u2003mg. For urinary LTE<jats:sub>4<\/jats:sub> at baseline no differences were found between the mean values for the different groups. After specific challenge, only C2 patients showed significantly increased excretion rates of urinary LTE<jats:sub>4<\/jats:sub> compared with the other groups challenged with placebo (A, B1, C1), or ASA (B2) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). No significant correlation was seen between urinary LTE<jats:sub>4<\/jats:sub> and methylhistamine excretion rate in any patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our results show that urinary excretion of N\u2010MH and LTE<jats:sub>4<\/jats:sub> is different for CU patients without ASA or food hypersensitivity, compared to those with CU with ASA or food additive hypersensitivity after specific challenge.<\/jats:p>","DOI":"10.1034\/j.1398-9995.2002.23767.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:48:29Z","timestamp":1047347309000},"page":"1180-1186","source":"Crossref","is-referenced-by-count":27,"title":["Urinary metabolites of histamine and leukotrienes before and after placebo\u2010controlled challenge with ASA and food additives in chronic urticaria patients"],"prefix":"10.1111","volume":"57","author":[{"given":"G.","family":"Di Lorenzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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