{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:10:52Z","timestamp":1793254252855,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Cohort studies have indicated that the survival of individuals with Down's syndrome has dramatically increased over the past 50\u2003years. Early childhood survival in particular has shown major improvement, due largely to advances in cardiac surgery and in general health management. The present study was based on a continuous cohort of 1332 people with Down's syndrome in Western Australia, registered for intellectual disability services between 1953 and 2000. Their life expectancy was 58.6\u2003years, 25% lived to 62.9\u2003years, and the oldest living person is 73\u2003years of age. Life expectancy for males was greater than females by 3.3\u2003years. The substantial increase in survival across the study period means that the life expectancy of people with Down's syndrome is approaching that of the general population, but accompanied by a range of significant mid\u2010life health problems. The findings are of relevance to all developed countries and have considerable implications in terms of the counselling information provided to families at risk of having a child with Down's syndrome.<\/jats:p>","DOI":"10.1034\/j.1399-0004.2002.620506.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T11:30:32Z","timestamp":1047382232000},"page":"390-393","source":"Crossref","is-referenced-by-count":320,"title":["The changing survival profile of people with Down's syndrome: implications for genetic counselling"],"prefix":"10.1111","volume":"62","author":[{"given":"EJ","family":"Glasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SG","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BA","family":"Petterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PD","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH","family":"Bittles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80395-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.12.764"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1999.00198.x"},{"key":"e_1_2_6_5_2","first-page":"44","article-title":"Study of Down syndrome in 238,942 consecutive births","volume":"41","author":"Stoll C","year":"1998","journal-title":"Ann Genet"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009084"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.1997.d01-25.x"},{"key":"e_1_2_6_8_2","volume-title":"Disability counts: a profile of disability in Western Australia.","author":"Alessandri L","year":"1996"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.7.M470"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1992.tb126421.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1192\/bjp.95.400.685","article-title":"The incidence of Mongolism in the general population","volume":"95","author":"Penrose LS.","year":"1949","journal-title":"J Ment Sci"},{"key":"e_1_2_6_12_2","first-page":"463","article-title":"Racial disparities in median age at death of persons with Down syndrome \u2013 United States, 1968\u201397. Centers for Disease Control and Prevention","volume":"50","author":"Friedman JM.","year":"2001","journal-title":"Morbidity Mortality Weekly Report"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/096382899297710"},{"key":"e_1_2_6_14_2","first-page":"53","article-title":"A life table for mongols in Victoria, Australia","volume":"7","author":"Collmann RD","year":"1963","journal-title":"J Ment Defic Res"},{"key":"e_1_2_6_15_2","first-page":"235","article-title":"Life tables up to age 10 for Mongols with and without congenital heart defect","volume":"14","author":"Fabia J","year":"1970","journal-title":"J Ment Defic Res"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00858.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.4.822"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2000.00252.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.1994.tb00343.x"},{"key":"e_1_2_6_20_2","first-page":"101","article-title":"Survival in Down's syndrome","volume":"30","author":"Fryers T.","year":"1986","journal-title":"J Ment Defic Res"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289703600603"},{"key":"e_1_2_6_22_2","volume-title":"Mental retardation. Definition, classification, and system of supports.","author":"AAMR.","year":"1992"},{"key":"e_1_2_6_23_2","first-page":"1","article-title":"A manual on terminology and classification in mental retardation","volume":"64","author":"Heber R.","year":"1959","journal-title":"Am J Ment Defic"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","DOI":"10.18356\/2e565da3-en","volume-title":"Human Development Report 2001.","author":"United Nations Development Programme.","year":"2001"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08092-3"},{"key":"e_1_2_6_26_2","unstructured":"GlassonEJ SullivanSG HussainR PettersonBA MontgomeryPD BittlesAH.The comparative survival advantage of males with Down syndrome.Am J Hum Biol(in press)."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00798209"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2000.00305.x"},{"key":"e_1_2_6_29_2","first-page":"187","article-title":"Down's syndrome and thyroid disorder","volume":"34","author":"Dinani S","year":"1990","journal-title":"J Ment Defic Res"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520440031017"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990625)89:2<100::AID-AJMG8>3.0.CO;2-N"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00480.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3148.2001.00067.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7291.875"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-0004.2002.620506.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1399-0004.2002.620506.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1399-0004.2002.620506.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T23:06:32Z","timestamp":1697497592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1399-0004.2002.620506.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1034\/j.1399-0004.2002.620506.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1399-0004.2002.620506.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}