{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:49:07Z","timestamp":1792626547015,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,5,7]],"date-time":"2002-05-07T00:00:00Z","timestamp":1020729600000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>Children with cholestatic liver disease have been thought to develop hepatic osteodystrophy resulting from vitamin D and calcium malabsorption, resulting in secondary hyperparathyroidism and osteomalacia or rickets. However, treatment with vitamin D has not always proven successful in improving the bone disturbance. The aim of our study was to determine the role of vitamin D deficiency in the pathogenesis of hepatic osteodystrophy. We studied five patients, three female and two male, ages 0.9\u201319\u2003yr, with biopsy\u2010proven chronic cholestatic liver disease and previously low serum levels of vitamin D despite oral intake of vitamin D preparations. Patients were admitted to the Clinical Research Center for 8\u2003days for sunlight deprivation and ultraviolet light substitution and for determinations of serum 25\u2010hyroxyvitamin D(25(OH)) D<jats:sub>2<\/jats:sub>and \u2010D<jats:sub>3<\/jats:sub>, osteocalcin, and type I collagen telopeptide (ICTP), the last two being markers of bone formation and resorption, respectively. Samples were taken on admission, at discharge, and 1\u2003month later. Results demonstrated low serum levels of osteocalcin and normal circulating levels of ICTP. Admission serum 25(OH)D<jats:sub>2<\/jats:sub>levels were uniformly low or undetectable and remained so. Admission levels of circulating 25(OH)D<jats:sub>3<\/jats:sub>were normal or low and did not rise during ultraviolet light therapy or subsequent resumption of oral vitamin D therapy and remained low 1\u2003month later. These results indicate that in the face of low\u2013normal to low total 25(OH)D levels, the low osteocalcin and normal ICTP levels suggest that decreased bone formation and not increased bone resorption is the main determinant of bone loss in a subset of children with chronic cholestatic liver disease.<\/jats:p>","DOI":"10.1034\/j.1399-3046.2002.01060.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:58:38Z","timestamp":1047495518000},"page":"136-140","source":"Crossref","is-referenced-by-count":41,"title":["Hepatic osteodystrophy in chronic cholestasis: Evidence for a multifactorial etiology"],"prefix":"10.1034","volume":"6","author":[{"given":"Gordon L.","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenville","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig B.","family":"Langman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,7]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"306","volume-title":"Primer on the Meta\u2010bolic Bone Diseases and Disorders of Mineral Metabolism","author":"Rao DS","year":"1996"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120520"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90783-X"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556312"},{"key":"e_1_2_7_6_2","first-page":"95","volume-title":"Dermatological Photobiology.","author":"Marquis IA.","year":"1976"},{"key":"e_1_2_7_7_2","first-page":"1151","volume-title":"Vitamin D: Chemical Biochemical, and Clinical Endocrinology of Calcium Metabolism.","author":"Holick MF","year":"1982"},{"key":"e_1_2_7_8_2","first-page":"114","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Eyre DR","year":"1996"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080311"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00279-1"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jbmr.5650080202","article-title":"Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry","volume":"8","author":"Eriksen EF","year":"1993","journal-title":"J Bone Miner Res"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/clinchem\/24.2.287","article-title":"Assay of vitamin D2 and D3 and 25\u2010hydroxyvitamin D2 and D3 in human plasma by high pressure liquid chromatography","volume":"24","author":"Jones G","year":"1978","journal-title":"Clin Chem"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81605-1"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70553-8"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80204-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1978.tb16274.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.5.367"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070127"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199709000-00010"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80351-6"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80243-7"},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0016-5085(82)80291-6","article-title":"Osteoporosis in primary biliary cirrhosis. 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